The polymorphisms of methionine synthase (MTR) and methionine synthase reductase (MTRR) genes in pathogenesis of preeclampsia

The aim of the study was to determine the MTR (methionine synthase) and MTRR (mehionine synthase reductase) polymorphisms in pregnant women with preeclampsia (PE).The group of 98 women with PE and the group of 120 healthy pregnant women were analyzed. Determination of MTR 2756A G and MTRR 66A G polymorphisms was performed using polymerase chain reaction (PCR)/restriction fragment length polymorphism (RFLP) method.The study did not show any statistically significant differences in frequency of genotypes and alleles of MTR 2756A G polymorphism between PE group and controls. Higher frequency of 66GG genotype and 66G allele of MTRR 66A G polymorphism was observed in the women with PE compared to control group. Moreover, the 66GG genotype correlated with higher doses of methyldopa, lower birth weight and higher placenta weight in women with PE.The obtained results for 66A G polymorphism of MTRR gene suggest the predisposition to PE in carriers of mutated 66GG genotype and - 66G allele.