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Nuclear shape as a prognostic discriminant in colorectal carcinoma
- Source :
- Diseases of the Colon & Rectum. 34:249-259
- Publication Year :
- 1991
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1991.
-
Abstract
- In search for a more reliable prognostic discriminant, a retrospective analysis of 100 cases of colorectal carcinoma having undergone curative resection and followed for at least 5 years were assessed by nuclear morphometry. Each case was staged according to the Dukes' classification as well as graded histologically. For all patients in this series, the perimeter, area, and nuclear shape factor of 50 interphase nuclei were determined for each carcinoma. The information was obtained through the use of an image analysis system by tracing the nuclear profiles (magnification 1000x) as digitized on a video screen. The nuclear shape factor was defined as the degree of circularity of the nucleus, a perfect circle recorded as 1.0. A nuclear shape factor greater than 0.84 was associated with poor outcome. Multiple regression models showed that the single nuclear parameter of the shape factor was the most highly significant predictor of survival (P less than 0.0001). This variable remained highly significant even when corrected for sex, age, histologic grade, and Dukes' classification. These findings indicate that a nuclear shape factor greater than or equal to 0.84 as determined by nuclear morphometry is an independent morphometric nuclear variable of great importance in the prognosis of large bowel carcinoma.
- Subjects :
- Adult
Male
Colorectal cancer
Magnification
Perimeter
Linear regression
Image Processing, Computer-Assisted
medicine
Carcinoma
Humans
Shape factor
Interphase
Aged
Neoplasm Staging
Retrospective Studies
Cell Nucleus
Analysis of Variance
Epithelioma
business.industry
Gastroenterology
General Medicine
Middle Aged
Prognosis
medicine.disease
Survival Rate
Cell nucleus
medicine.anatomical_structure
Regression Analysis
Female
Colorectal Neoplasms
Nuclear medicine
business
Subjects
Details
- ISSN :
- 00123706
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Diseases of the Colon & Rectum
- Accession number :
- edsair.doi.dedup.....070b89b40337a4badf0696d8e96f970f