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Retinal blood flow speed quantification at the capillary level using temporal autocorrelation fitting OCTA [Invited]
- Source :
- Biomed Opt Express
- Publication Year :
- 2023
- Publisher :
- Optica Publishing Group, 2023.
-
Abstract
- Optical coherence tomography angiography (OCTA) can visualize vasculature structures, but provides limited information about blood flow speed. Here, we present a second generation variable interscan time analysis (VISTA) OCTA, which evaluates a quantitative surrogate marker for blood flow speed in vasculature. At the capillary level, spatially compiled OCTA and a simple temporal autocorrelation model, ρ(τ) = exp(-ατ), were used to evaluate a temporal autocorrelation decay constant, α, as the blood flow speed marker. A 600 kHz A-scan rate swept-source OCT prototype instrument provides short interscan time OCTA and fine A-scan spacing acquisition, while maintaining multi mm2 field of views for human retinal imaging. We demonstrate the cardiac pulsatility and assess repeatability of α measured with VISTA. We show different α for different retinal capillary plexuses in healthy eyes and present representative VISTA OCTA in eyes with diabetic retinopathy.
- Subjects :
- Atomic and Molecular Physics, and Optics
Article
Biotechnology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Biomed Opt Express
- Accession number :
- edsair.doi.dedup.....070322c677fc0877b0987c143dbacda3