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Retinal blood flow speed quantification at the capillary level using temporal autocorrelation fitting OCTA [Invited]

Authors :
Yunchan Hwang
Jungeun Won
Antonio Yaghy
Hiroyuki Takahashi
Jessica M. Girgis
Kenneth Lam
Siyu Chen
Eric M. Moult
Stefan B. Ploner
Andreas Maier
Nadia K. Waheed
James G. Fujimoto
Source :
Biomed Opt Express
Publication Year :
2023
Publisher :
Optica Publishing Group, 2023.

Abstract

Optical coherence tomography angiography (OCTA) can visualize vasculature structures, but provides limited information about blood flow speed. Here, we present a second generation variable interscan time analysis (VISTA) OCTA, which evaluates a quantitative surrogate marker for blood flow speed in vasculature. At the capillary level, spatially compiled OCTA and a simple temporal autocorrelation model, ρ(τ) = exp(-ατ), were used to evaluate a temporal autocorrelation decay constant, α, as the blood flow speed marker. A 600 kHz A-scan rate swept-source OCT prototype instrument provides short interscan time OCTA and fine A-scan spacing acquisition, while maintaining multi mm2 field of views for human retinal imaging. We demonstrate the cardiac pulsatility and assess repeatability of α measured with VISTA. We show different α for different retinal capillary plexuses in healthy eyes and present representative VISTA OCTA in eyes with diabetic retinopathy.

Details

Language :
English
Database :
OpenAIRE
Journal :
Biomed Opt Express
Accession number :
edsair.doi.dedup.....070322c677fc0877b0987c143dbacda3