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Heterogeneity in phenotypes based on smoking status in the Great Lakes Smoker Sibling Registry
- Source :
- Addictive behaviors. 29(9)
- Publication Year :
- 2004
-
Abstract
- We investigated whether 52 same-sex sibling pairs discordant for ever-smoking differed on psychiatric cofactors, alcohol and caffeine use, and responses to initial exposure to smoking. Ever-smokers scored significantly higher on measures of novelty seeking, depression, and childhood ADHD, and on alcohol dependence, alcohol intake, and caffeine intake. They reported significantly more pleasurable experiences, dizziness, "buzz," and relaxation upon initial exposure to smoking and significantly fewer displeasurable sensations, nausea, and cough than did nicotine-exposed, never-smoking siblings. Ever-smokers had significantly fewer years of education than their never-smoking siblings, suggesting that the concentration of smokers in lower socioeconomic strata may be partly due to downward mobility among smokers, possibly because of the observed elevation in psychiatric cofactors, which may interfere with academic performance. These findings are consistent with differences previously identified in unrelated ever- and never-smokers. Because same-sex siblings typically share a large set of common environments during childhood, our findings could be due either to genetic differences among siblings and/or (excepting educational level and responses to early exposure) to differences in adult environments.
- Subjects :
- Adult
Male
medicine.medical_specialty
Alcohol Drinking
Nausea
Medicine (miscellaneous)
Toxicology
Caffeine
medicine
Humans
Registries
Sibling
Psychiatry
Socioeconomic status
Depression (differential diagnoses)
Depression
Siblings
Alcohol dependence
Smoking
Novelty seeking
Psychiatry and Mental health
Clinical Psychology
Phenotype
Attention Deficit Disorder with Hyperactivity
Educational Status
Alcohol intake
Smoking status
Female
medicine.symptom
Psychology
Alcohol-Related Disorders
Demography
Subjects
Details
- ISSN :
- 03064603
- Volume :
- 29
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Addictive behaviors
- Accession number :
- edsair.doi.dedup.....06f299aeefb02cb2b3f5a0bce03b1a93