Back to Search
Start Over
Nanovectorization of TRAIL with single wall carbon nanotubes enhances tumor cell killing
- Source :
- Nano Letters, Nano Letters, American Chemical Society, 2015, [Epub ahead of print]. ⟨10.1021/nl503565t⟩, Nano Letters, American Chemical Society, 2015, 15 (2), pp.891-895. ⟨10.1021/nl503565t⟩, Nano Letters, American Chemical Society, 2015, 15 (2), [Epub ahead of print]. ⟨10.1021/nl503565t⟩, Nano Letters, American Chemical Society, 2015, [Epub ahead of print]. 〈10.1021/nl503565t〉, Nano Letters, 2015, 15 (2), [Epub ahead of print]. ⟨10.1021/nl503565t⟩
- Publication Year :
- 2015
- Publisher :
- HAL CCSD, 2015.
-
Abstract
- International audience; Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL or Apo2L) is a member of the tumor necrosis factor (TNF) superfamily. This type II transmembrane protein is able to bound specifically to cancer cell receptors (i.e., TRAIL-R1 (or DR4) and TRAIL-R2 (or DR5)) and to induce apoptosis without being toxic for healthy cells. Because membrane-bound TRAIL induces stronger receptor aggregation and apoptosis than soluble TRAIL, we proposed here to vectorize TRAIL using single-walled carbon nanotubes (SWCNTs) to mimic membrane TRAIL. Owing to their exceptional and revolutional properties, carbon nanotubes, especially SWCNTs, are used in a wide range of physical or, now, medical applications. Indeed due to their high mechanical resistance, their high flexibility and their hydrophobicity, SWCNTs are known to rapidly diffuse in an aqueous medium such as blood, opening the way of development of new drug nanovectors (or nanocarriers). Our TRAIL-based SWCNTs nanovectors proved to be more efficient than TRAIL alone death receptors in triggering cancer cell killing. These NPTs increased TRAIL pro-apoptotic potential by nearly 20-fold in different Human tumor cell lines including colorectal, nonsmall cell lung cancer, or hepatocarcinomas. We provide thus a proof-of-concept that TRAIL nanovector derivatives based on SWCNT may be useful to future nanomedicine therapies.
- Subjects :
- Materials science
[SDV.BIO]Life Sciences [q-bio]/Biotechnology
Stereochemistry
Carbon nanotubes
Bioengineering
TRAIL
02 engineering and technology
TNF-Related Apoptosis-Inducing Ligand
03 medical and health sciences
Microscopy, Electron, Transmission
Cell Line, Tumor
Neoplasms
[SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology
Humans
[CHIM]Chemical Sciences
General Materials Science
[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
Receptor
[ SDV.BBM ] Life Sciences [q-bio]/Biochemistry, Molecular Biology
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
Receptor Aggregation
0303 health sciences
Nanotubes, Carbon
Mechanical Engineering
nanovector
[ SDV.BIO ] Life Sciences [q-bio]/Biotechnology
General Chemistry
021001 nanoscience & nanotechnology
Condensed Matter Physics
nanomedicine
Transmembrane protein
[SDV.BIO] Life Sciences [q-bio]/Biotechnology
Receptors, TNF-Related Apoptosis-Inducing Ligand
Cell culture
Apoptosis
Cancer cell
Cancer research
cancer therapy
death receptor
Tumor necrosis factor alpha
Nanocarriers
0210 nano-technology
Subjects
Details
- Language :
- English
- ISSN :
- 15306984 and 15306992
- Database :
- OpenAIRE
- Journal :
- Nano Letters, Nano Letters, American Chemical Society, 2015, [Epub ahead of print]. ⟨10.1021/nl503565t⟩, Nano Letters, American Chemical Society, 2015, 15 (2), pp.891-895. ⟨10.1021/nl503565t⟩, Nano Letters, American Chemical Society, 2015, 15 (2), [Epub ahead of print]. ⟨10.1021/nl503565t⟩, Nano Letters, American Chemical Society, 2015, [Epub ahead of print]. 〈10.1021/nl503565t〉, Nano Letters, 2015, 15 (2), [Epub ahead of print]. ⟨10.1021/nl503565t⟩
- Accession number :
- edsair.doi.dedup.....06f1ebda94e07a93a16850a9e376d80e