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Maximum standardized uptake value at pre-treatment PET in estimating lung cancer progression after stereotactic body radiotherapy
- Source :
- Radiation Oncology Journal
- Publication Year :
- 2019
-
Abstract
- Purpose This study aimed to identify the feasibility of the maximum standardized uptake value (SUVmax) on baseline 18F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET/CT) as a predictive factor for prognosis in early stage primary lung cancer treated with stereotactic body radiotherapy (SBRT). Materials and methods Twenty-seven T1-3N0M0 primary lung cancer patients treated with curative SBRT between 2010 and 2018 were retrospectively evaluated. Four patients (14.8%) treated with SBRT to address residual tumor after wedge resection and one patient (3.7%) with local recurrence after resection were included. The SUVmax at baseline PET/CT was assessed to determine its relationship with prognosis after SBRT. Patients were divided into two groups based on maximum SUVmax on pre-treatment FDG PET/CT, estimated by receiver operating characteristic curve. Results The median follow-up period was 17.7 months (range, 2.3 to 60.0 months). The actuarial 2-year local control, progressionfree survival (PFS), and overall survival were 80.4%, 66.0%, and 78.2%, respectively. With regard to failure patterns, 5 patients exhibited local failure (in-field failure, 18.5%), 1 (3.7%) experienced regional nodal relapse, and other 2 (7.4%) developed distant failure. SUVmax was significantly correlated with progression (p = 0.08, optimal cut-off point SUVmax > 5.1). PFS was significantly influenced by pretreatment SUVmax (SUVmax > 5.1 vs. SUVmax ≤ 5.1; p = 0.012) and T stage (T1 vs. T2-3; p = 0.012). Conclusion SUVmax at pre-treatment FDG PET/CT demonstrated a predictive value for PFS after SBRT for lung cancer.
- Subjects :
- Stereotactic body radiotherapy
Clinical Investigations
Standardized uptake value
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Lung neoplasms
medicine
Radiology, Nuclear Medicine and imaging
Progression-free survival
Stage (cooking)
Lung cancer
medicine.diagnostic_test
Receiver operating characteristic
business.industry
medicine.disease
Oncology
Positron emission tomography
030220 oncology & carcinogenesis
T-stage
Original Article
Positron-emission tomography
business
Nuclear medicine
Wedge resection (lung)
Subjects
Details
- ISSN :
- 22341900
- Volume :
- 37
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Radiation oncology journal
- Accession number :
- edsair.doi.dedup.....06f0de5d675636c89afcc9f7cbaffdbd