Back to Search
Start Over
Sulfide as a Mucus Barrier-Breaker in Inflammatory Bowel Disease?
- Source :
- Trends in molecular medicine, 22(3), 190. Elsevier Limited
- Publication Year :
- 2015
-
Abstract
- The gut epithelium is covered by mucus consisting of mucin polymers connected via disulfide bonds. The mucus layer limits exposure of epithelial cells to toxins and bacteria. A recent study has shown that sulfide, produced by certain bacteria, reduces disulfide bonds in the mucus network. The resulting breaks in the mucus barrier allow exposure of the epithelium to bacteria and toxins, causing inflammation. In this opinion article we argue that this mechanism may be involved in the etiology and/or severity of inflammatory bowel disease (IBD) because IBD is associated with decreased mucus barrier function, altered microbial species, and increased sulfide concentrations. Increasing the mucus integrity by reducing sulfide concentrations in the intestine may be a novel therapeutic option for IBD.
- Subjects :
- 0301 basic medicine
Sulfide
Biology
Sulfides
Inflammatory bowel disease
Microbiology
03 medical and health sciences
0302 clinical medicine
fluids and secretions
medicine
Animals
Humans
Sulfate-reducing bacteria
Intestinal Mucosa
Molecular Biology
Barrier function
chemistry.chemical_classification
Sulfates
Mucin
respiratory system
medicine.disease
Inflammatory Bowel Diseases
Mucus
Epithelium
Gut Epithelium
Gastrointestinal Microbiome
030104 developmental biology
medicine.anatomical_structure
chemistry
030220 oncology & carcinogenesis
Molecular Medicine
Subjects
Details
- ISSN :
- 1471499X and 14714914
- Volume :
- 22
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Trends in molecular medicine
- Accession number :
- edsair.doi.dedup.....06eeb98f984474b3e32641d37eb7c9cc