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Lactase Insufficiency Revisited
- Source :
- Journal of Pediatric Gastroenterology and Nutrition. 4:868-872
- Publication Year :
- 1985
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1985.
-
Abstract
- The definition of "insufficient" small bowel lactase activity varies greatly among authors. The present study is aimed at redefining lactase insufficiency by comparing intestinal lactase activity and results of the lactose breath hydrogen test. Primary "insufficient" lactase activity was considered to be present when a child with a normal small bowel histology showed lactose malabsorption as measured by the lactose breath hydrogen test. The lactase activity of 22 "normal" children ranged from 0.77 to 4.57 U/g wet weight, while five children showed primary lactase insufficiency as defined above. Small bowel lactase activity in the latter patients was less than 0.74 U/g wet weight. Sucrase and maltase activities were similar in both groups of patients. We conclude that children with a normal small bowel histology should be considered to have primary lactase insufficiency when small bowel lactase activity is below 0.75 U/g wet weight.
- Subjects :
- Male
medicine.medical_specialty
Adolescent
Gastrointestinal Diseases
medicine.medical_treatment
Respiratory Tract Diseases
Lactose
Gastroenterology
Lactase activity
chemistry.chemical_compound
Lactose Intolerance
Internal medicine
Intestine, Small
medicine
Humans
Child
Breath test
Intestinal lactase
medicine.diagnostic_test
business.industry
Respiration
Infant
alpha-Glucosidases
Lactase
beta-Galactosidase
Breath hydrogen test
Galactosidases
chemistry
Child, Preschool
Pediatrics, Perinatology and Child Health
Female
business
Hydrogen
Sucrase
Subjects
Details
- ISSN :
- 02772116
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of Pediatric Gastroenterology and Nutrition
- Accession number :
- edsair.doi.dedup.....06ec27732963547c0bc45568e6b22976