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Early increase of NOX2-derived oxidative stress in children: relationship with age
- Source :
- Pediatric Research. 73:788-793
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- Studies conducted in the prepubertal period showed that biomarkers of oxidative stress decreased with increasing age in normocholesterolemic children (NC), and, conversely, they are persistently high in hypercholesterolemic children (HC). Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is the most important cellular source of reactive oxygen species. No data have been reported concerning the behavior of age-related oxidative stress generated by NOX2, the catalytic subunit of NADPH oxidase, in children. We performed a cross-sectional study comparing oxidized low-density lipoprotein (ox-LDL), as a marker of oxidative stress, and NOX2 activity, as assessed by blood levels of soluble NOX2–derived peptide (sNOX2-dp), in a population of 250 children, including 125 NC and 125 HC. HC had higher sNOX2-dp (25.8 ± 16.1 pg/ml) and ox-LDL (23.6 ± 14.4 U/l) levels as compared with NC (15.4 ± 10.1 and 11.6 ± 6.4 pg/ml, respectively; P < 0.001). Multiple linear regression analysis showed that ox-LDL and total cholesterol were the only independent predictive variables associated with sNOX2-dp. In NC, ox-LDL and sNOX2-dp significantly decreased from the first to the second quintile of age. In HC, ox-LDL and sNOX2-dp levels did not show significant differences among quintiles of age. This study suggests that NOX2 contributes to generating ox-LDL during the early phase of life in NC and to the persistent high oxidative stress in the prepubertal period of HC.
- Subjects :
- Male
medicine.medical_specialty
Hypercholesterolemia
Population
medicine.disease_cause
chemistry.chemical_compound
Internal medicine
medicine
Humans
Child
education
chemistry.chemical_classification
Oxidase test
Reactive oxygen species
education.field_of_study
Membrane Glycoproteins
NADPH oxidase
biology
Age Factors
Case-control study
NADPH Oxidases
Oxidative Stress
Cross-Sectional Studies
Endocrinology
chemistry
Case-Control Studies
Child, Preschool
NADPH Oxidase 2
Pediatrics, Perinatology and Child Health
Immunology
biology.protein
Female
Nicotinamide adenine dinucleotide phosphate
Oxidative stress
Lipoprotein
Subjects
Details
- ISSN :
- 15300447 and 00313998
- Volume :
- 73
- Database :
- OpenAIRE
- Journal :
- Pediatric Research
- Accession number :
- edsair.doi.dedup.....06e77171139a1b7bdc715158c076161e