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Phylogenetic and evolutionary analysis of HoBi‐like pestivirus: Insights into origin and dispersal
- Source :
- Transboundary and Emerging Diseases.
- Publication Year :
- 2020
- Publisher :
- Hindawi Limited, 2020.
-
Abstract
- The HoBi-like pestivirus (HoBiPeV), currently classified as Pestivirus H species, is a pathogen associated with a broad spectrum of clinical manifestations in ruminants, particularly in cattle. Since HoBiPeV complete genome sequencing data is scarce, in the present study we described five nearly complete new Brazilian HoBiPeV genomes and further perform a more complete genetic and evolutionary characterization with all additional genome sequences available in the GenBank database. Entropy and selection pressure analysis showed the E2 gene, a surface glycoprotein, is the most variable gene, which also displays the greatest number of sites under positive selection. Phylogenetic and Bayesian inference based on complete genome and Npro gene, respectively, from all HoBiPeV sequences available so far, confirms the existence of three main clades (a, b, and c). The abovementioned analysis suggests that this pestivirus species probably emerged in Asia and spread to different regions including Brazil, where only strains belonging to specific genetic group 'a' have been found. The hypothesis of the HoBiPeV introduction in Brazil (between 1,890 and 1,962), formulated based on Bayesian inference, coincides with a period of intensive importation of water buffalo (Bubalus arnee) and indicine cattle (Bos taurus indicus) from Asia to Brazil, suggesting that this could be the origin of the current Brazilian HoBiPeV genetic group 'a'.
- Subjects :
- Whole genome sequencing
0303 health sciences
General Veterinary
General Immunology and Microbiology
biology
Phylogenetic tree
040301 veterinary sciences
Pestivirus
04 agricultural and veterinary sciences
General Medicine
biology.organism_classification
Genome
Bubalus arnee
0403 veterinary science
03 medical and health sciences
Phylogenetics
Evolutionary biology
GenBank
Clade
030304 developmental biology
Subjects
Details
- ISSN :
- 18651682 and 18651674
- Database :
- OpenAIRE
- Journal :
- Transboundary and Emerging Diseases
- Accession number :
- edsair.doi.dedup.....06dd90542ffcb7bcea9c94e2fee8a933