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Association between Use of Oral Anti-Diabetic Drugs and the Risk of Sepsis: A Nested Case-Control Study

Authors :
Pei Wen Chao
Chia Jen Shih
Shu-Chen Kuo
Chih Yu Yang
Szu Yuan Li
Shuo Ming Ou
Yueh Lin Wu
Yung Tai Chen
Source :
Scientific Reports
Publication Year :
2015

Abstract

Although oral antidiabetic drugs (OADs) have been associated with immunomodulation in preclinical studies, little is still known about the association between the use of OADs and the risk of sepsis. Using a cohort of patients, extracted from Taiwan’s National Health Insurance Research Database, with type 2 diabetes who were newly diagnosed between 2010 and 2012 and treated with OADs, we conducted a nested case-control study involving 43,015 cases (patients who were first hospitalized for sepsis) and 43,015 matched controls. Compared with non-use, metformin use was associated with a decreased risk of developing sepsis (adjusted odds ratio [OR] 0.80, 95% confidence interval [CI] 0.77–0.83, P P

Details

ISSN :
20452322
Volume :
5
Database :
OpenAIRE
Journal :
Scientific reports
Accession number :
edsair.doi.dedup.....06d739fb8a8bea95b95bc501f865c70e