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Interaction of 5-substituted pyrimidine nucleoside analogues and M.Tuberculosis: A view through an electron microscope
- Source :
- Biochimie. :170-177
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- The data of transmission electron microscopy (TEM) on morphology of M. tuberculosis H37Rv bacterial cells treated with four analogues of pyrimidine nucleosides with different substituents at 5 position of base are presented. We showed that the growth of M. tuberculosis H37Rv cells effectively inhibited by each of these compounds. This process is accompanied with the accumulation of lipid intracellular vacuole-like inclusions in the cells, appearance of deep protrusions and indentations on the surface, partial and/or complete destruction of the three-layered cell envelope. The exact molecular mechanism of action of 5-substituted pyrimidine nucleosides on M. tuberculosis cells remains to be proved. However, one can suggest that mechanism of action for these compounds is related either to their direct interactions with bacteria cell walls or to interactions with enzymes participating in the process of cell wall formation.
- Subjects :
- 0301 basic medicine
chemistry.chemical_classification
030102 biochemistry & molecular biology
Pyrimidine
Chemistry
Mycobacterium tuberculosis
General Medicine
Pyrimidine Nucleosides
Biochemistry
Bacterial cell structure
law.invention
03 medical and health sciences
chemistry.chemical_compound
030104 developmental biology
Enzyme
Microscopy, Electron, Transmission
Mechanism of action
law
medicine
Biophysics
medicine.symptom
Electron microscope
Cell envelope
Nucleoside
Intracellular
Subjects
Details
- ISSN :
- 03009084
- Database :
- OpenAIRE
- Journal :
- Biochimie
- Accession number :
- edsair.doi.dedup.....06cbe6e5bcb2fcc95cc0644a3811d2ee