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Analysis of the gene polymorphism of aldosterone synthase (CYP11B2) and atrial natriuretic peptide (ANP) in women with preeclampsia
- Source :
- European journal of obstetrics, gynecology, and reproductive biology. 197
- Publication Year :
- 2015
-
Abstract
- Objective Preeclampsia (PE) is a major cause of mortality of mothers, fetuses and newborns around the world. The etiology of preeclampsia has not yet been clarified, but many studies indicate a multifactorial basis of PE. Aldosterone synthase (CYP11B2) is responsible for synthesis of aldosterone responsible for regulating blood pressure. Similarly, natriuretic peptide (ANP) regulates blood pressure through a variety of mechanisms affecting the sodium concentration and the amount of extracellular fluid. Currently, attention is paid to the role of the polymorphisms in the expression level of these genes. The aim of the study was to determine the frequencies of genotypes and alleles for polymorphisms of −344C > T CYP11B2 gene and 2238T > C ANP gene in women with preeclampsia and healthy pregnant women from the Caucasian population. Study design The study included a group of 165 pregnant women (59 women with preeclampsia and 109 healthy pregnant women). DNA was extracted from peripheral blood. Determination of the polymorphism of −344C > T CYP11B2 gene and 2238T > C ANP gene was performed by PCR-RFLP method. Results The results showed that the frequencies of the TC and CC genotypes of 2238T > C polymorphism in ANP gene were significantly higher in patients with PE compared to control group. For −344C > T polymorphism of CYP11B2 gene, the frequency of TT genotype was significantly higher in patients with hypertension than in controls (32.2% vs. 23.58%). Conclusions Our findings showed that gene polymorphism of CYP11B2 (−344C > T) and ANP (2238T > C) may be associated with developing PE during pregnancy.
- Subjects :
- Aldosterone synthase
Adult
medicine.medical_specialty
Genotype
medicine.drug_class
030209 endocrinology & metabolism
Blood Pressure
030204 cardiovascular system & hematology
Polymerase Chain Reaction
White People
Preeclampsia
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Atrial natriuretic peptide
Gene Frequency
Pre-Eclampsia
Polymorphism (computer science)
Pregnancy
Internal medicine
medicine
Natriuretic peptide
Cytochrome P-450 CYP11B2
Humans
Genetic Predisposition to Disease
Aldosterone
Polymorphism, Genetic
biology
business.industry
Body Weight
Obstetrics and Gynecology
Hypertension, Pregnancy-Induced
medicine.disease
Blood pressure
Endocrinology
Reproductive Medicine
chemistry
Case-Control Studies
biology.protein
Female
Gene polymorphism
business
Atrial Natriuretic Factor
Polymorphism, Restriction Fragment Length
Subjects
Details
- ISSN :
- 18727654
- Volume :
- 197
- Database :
- OpenAIRE
- Journal :
- European journal of obstetrics, gynecology, and reproductive biology
- Accession number :
- edsair.doi.dedup.....06c1ae566097f39f22a6aef38d8f39ff