Back to Search
Start Over
The Predictive Role of Biomarkers for the Detection of Acute Kidney Injury After Partial or Radical Nephrectomy: A Systematic Review of the Literature
- Publication Year :
- 2020
-
Abstract
- Context Postoperative acute kidney injury (AKI) is a serious complication after kidney surgery, associated with prolonged hospital stay, high morbidity, and mortality. Biomarkers represent a tool of increasing importance to identify renal impairment after partial nephrectomy (PN) or radical nephrectomy (RN) in order to optimize and anticipate the diagnosis of AKI. Objective The goal of this systematic review is to investigate current insights on the role of biomarkers in predicting renal impairment in patients undergoing PN or RN. Evidence acquisition A systematic review was conducted up to November 30, 2017 through PubMed, Scopus, and Embase databases, to identify eligible studies evaluating the role of biomarkers for the prediction of AKI after PN or RN. The Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) criteria were applied to select articles. Evidence synthesis According to the study selection criteria, 10 publications were included with a total number of 728 patients. Incidence of AKI was 26.7% (range: 9–58%). Based on the evidence reviewed, serum cystatin C and urinary neutrophil gelatinase-associated lipocalin (NGAL) showed a significant correlation with serum creatinine rise postoperatively, emerging as potential noninvasive and early biomarkers of AKI in patients undergoing renal surgery. In this setting, serum cystatin C and urinary NGAL have preceded the rise in serum creatinine peak from 3 up to 24 h, even in case of mild renal damage. Conclusions The literature underlines the potential usefulness of biomarkers such as cystatin C and NGAL as promising and early tools to predict AKI after PN or RN. However, no strong evidence in support of their use is available to date and further investigations are awaited. Patient summary We looked at the role of biomarkers in predicting renal injury in patients undergoing partial or radical nephrectomy. Serum cystatin C and urinary neutrophil gelatinase-associated lipocalin have emerged as promising noninvasive, accurate, and early biomarkers.
- Subjects :
- medicine.medical_specialty
Urinary system
medicine.medical_treatment
Urology
030232 urology & nephrology
Context (language use)
Acute kidney injury
Biomarkers
Cystatin C
Neutrophil gelatinase-associated lipocalin
Partial nephrectomy
Predictors
Radical nephrectomy
urologic and male genital diseases
Nephrectomy
biomarkersCystatin C
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Postoperative Complications
Predictive Value of Tests
medicine
Humans
Kidney surgery
acute kidney injury
partial nephrectomy
radical nephrectomy
Creatinine
biology
business.industry
renal carcinoma
Biomarker
medicine.disease
Systematic review
chemistry
030220 oncology & carcinogenesis
biology.protein
business
Predictor
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....06acf8e661448626bb3342b2002a8a78