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Changes in the diagnosis of congenital cardiovascular malformations during the 1st year of life: impacts on epidemiological risk factor associations
- Source :
- Cardiology in the Young. 27:770-781
- Publication Year :
- 2016
- Publisher :
- Cambridge University Press (CUP), 2016.
-
Abstract
- Many epidemiological studies base their classification of congenital cardiovascular malformations in newborns upon a single, initial diagnosis. This study aimed to evaluate the effect of subsequent diagnostic investigations on the results of epidemiological studies. We used diagnostic codes from the Baltimore-Washington Infant Study from the time of birth and at ~1 year of age. Odds ratios and 95% confidence intervals were used to identify associations between changes in diagnoses and infant characteristics, time period, that is, before and after introduction of color flow Doppler imaging, and diagnostic variables. Of the 3054 patients with data at both time points, 400 (13.1%) had diagnostic changes. For congenital cardiovascular malformations of early cardiogenesis, such as laterality and looping defects, conotruncal malformations, and atrioventricular septal defects, significant associations were observed between diagnostic change and case infants large for gestational age (odds ratio=0.22, p=0.01), diagnosed initially by echocardiography only (odds ratio=2.05, p=0.001), or with non-cardiac malformations (odds ratio=0.60, p=0.03). For all other congenital cardiovascular malformations, significant associations were observed with echocardiography-only diagnosis (odds ratio=1.43, p=0.04) and non-cardiac malformations (odds ratio=0.57, p
- Subjects :
- Heart Defects, Congenital
Male
Pediatrics
medicine.medical_specialty
Time Factors
Gestational Age
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Risk Factors
Epidemiology
Humans
Medicine
030212 general & internal medicine
Medical diagnosis
Risk factor
business.industry
Infant, Newborn
Infant
Gestational age
General Medicine
Odds ratio
United States
Confidence interval
Echocardiography, Doppler, Color
Logistic Models
Case-Control Studies
Multivariate Analysis
Pediatrics, Perinatology and Child Health
Female
Cardiovascular malformations
Diagnosis code
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 14671107 and 10479511
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Cardiology in the Young
- Accession number :
- edsair.doi.dedup.....06a03fc44bd93fc4ebdbe6dc25a5a09a