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Squaraines as Fluoro−Chromogenic Probes for Thiol-Containing Compounds and Their Application to the Detection of Biorelevant Thiols
- Source :
- Journal of the American Chemical Society. 126:4064-4065
- Publication Year :
- 2004
- Publisher :
- American Chemical Society (ACS), 2004.
-
Abstract
- A highly selective colorimetric chemodosimeter for thiol-containing compounds in aqueous solutions is reported. The design protocol makes use of a highly specific reaction between thiols and the electrophilic four-membered ring of highly colored, fluorescent squaraine backbones. At neutral pH selective decoloration and total emission quenching was found due to the rupture of the highly delocalized squaraine framework upon selective nucleophilic addition of thiol-containing derivatives. The squaraine derivatives have been successfully applied to the determination of low-molecular mass aminothiols in human plasma. The method utters the high potential applicability of the chemodosimeter approach in the search for new or improved chromogenic selective or specific probes for target guests.
- Subjects :
- Fluorescence spectrometry
Biochemistry
Catalysis
Colloid and Surface Chemistry
Phenols
Animals
Organic chemistry
Cysteine
Sulfhydryl Compounds
Chromatography, High Pressure Liquid
Fluorescent Dyes
chemistry.chemical_classification
Aqueous solution
Nucleophilic addition
Chemistry
Chromogenic
Biphenyl Compounds
Dipeptides
General Chemistry
Glutathione
Combinatorial chemistry
Fluorescence
Spectrometry, Fluorescence
Electrophile
Thiol
Cyclobutanes
Subjects
Details
- ISSN :
- 15205126 and 00027863
- Volume :
- 126
- Database :
- OpenAIRE
- Journal :
- Journal of the American Chemical Society
- Accession number :
- edsair.doi.dedup.....069d32bfd83be0849d81881a02f15bb1