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Early Efficacy of Endostar Combined with Chemoradiotherapy for Advanced Cervical Cancers
- Source :
- Asian Pacific Journal of Cancer Prevention. 13:923-926
- Publication Year :
- 2012
- Publisher :
- Asian Pacific Organization for Cancer Prevention, 2012.
-
Abstract
- The aim of this study was to investigate the early outcome of Endostar combined with chemoradiotherapy for advanced cervical cancer. Fifty-two cases (FIGO Ⅱb to Ⅳa) were divided randomly into two groups, receiving chemoradiotherapy alone (CRT group) and Endostar combined with chemoradiotherapy (CRT+E group). For the patients in the CRT+E group, Endostar was administered daily with the dosage of 7.5 mg/m 2 , and cisplatin was administered weekly with the dosage of 20 mg/m 2 during the radiation. The regimens lasted for 4 weeks with no difference in chemoradiotherapy between the two groups. The early outcome complete remission rate was 73.1%, partial remission rate was 23.1% and the total response rate was 96.2% in CRT+E group, a significnat improvement on the 34.6%, 42.3% and 76.9%, respectively, in the CRT group. One year survive rates were 100% and 84.6% in the CRT+E group and CRT groups, the difference being significant. Endostar combined with chemoradiotherapy can improve the early outcome of the advanced cervical cancer, and adverse effects were not encountered.
- Subjects :
- Oncology
Cancer Research
medicine.medical_specialty
genetic structures
Epidemiology
Uterine Cervical Neoplasms
Total response
law.invention
Randomized controlled trial
law
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Adverse effect
Survival rate
Cisplatin
Cervical cancer
business.industry
Public Health, Environmental and Occupational Health
Complete remission
Chemoradiotherapy
Middle Aged
medicine.disease
Recombinant Proteins
Endostatins
Survival Rate
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 15137368
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Asian Pacific Journal of Cancer Prevention
- Accession number :
- edsair.doi.dedup.....068f5cfe79109df73583e2edcc8856c0