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Acute myeloid leukemia with 11q23 rearrangements: A study of therapy-related disease and therapeutic outcomes
- Source :
- Leuk Res
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- We described the clinical features and outcomes for 63 adult patients with acute myeloid leukemia (AML) with a translocation involving the 11q23 locus (MLL) who were treated at Memorial Sloan Kettering Cancer Center (MSK). The population included 40 female (63 %) and 23 male (37 %) patients, with a median age of 51 years old (range 18-82 years). Of the 31 patients who had had an antecedent malignancy, 14 (45 %) had had breast cancer or DCIS and 22 (71 %) had received anthracycline-based systemic chemotherapy. The translocation partner for the 11q23 rearrangement was identified in 60 of the 63 patients (95 %) studied. The distribution of translocation partners differed for those who had previously received cytotoxic chemotherapy. Most patients with therapy-related disease had a 9p22 or 19p13 partner, as compared to those with de novo disease (95 % vs. 68 %, p = 0.023). Of the 30 patients who received all therapy under observation, 15 (50 %) patients had de novo disease and 15 (50 %) had received antecedent chemotherapy. No significant difference in survival was observed between groups (p = 0.44). Twenty-two patients received induction as up-front therapy, of whom 11 (50 %) achieved CR / CRi. The achievement of CR / CRi with one course of induction was associated with improved OS, with a 6-month OS of 73 % as compared to 23 % for those who did not (p = 0.018). The achievement of CR / CRi with a single course of induction may be a marker of favorable survival in this subtype of high-risk AML. KEY POINT: Response to a single induction was associated with favorable survival in this population.
- Subjects :
- Adult
Male
Oncology
Cancer Research
medicine.medical_specialty
Adolescent
Anthracycline
medicine.medical_treatment
Population
Breast Neoplasms
Chromosomal translocation
Malignancy
Article
Translocation, Genetic
03 medical and health sciences
0302 clinical medicine
Breast cancer
Internal medicine
medicine
Humans
Anthracyclines
education
Aged
Aged, 80 and over
Chemotherapy
education.field_of_study
biology
business.industry
Chromosomes, Human, Pair 11
Myeloid leukemia
Neoplasms, Second Primary
Hematology
Middle Aged
medicine.disease
Leukemia, Myeloid, Acute
KMT2A
030220 oncology & carcinogenesis
biology.protein
Female
Chromosomes, Human, Pair 9
business
Chromosomes, Human, Pair 19
030215 immunology
Subjects
Details
- ISSN :
- 01452126
- Volume :
- 98
- Database :
- OpenAIRE
- Journal :
- Leukemia Research
- Accession number :
- edsair.doi.dedup.....0683a79f75330322468f00248c36d3d9