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Tumor accumulation of ε-poly-lysines-based polyamines conjugated with boron clusters
- Source :
- Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 69(12)
- Publication Year :
- 2010
-
Abstract
- Boron Neutron Capture Therapy (BNCT) is one of the potent cancer radiotherapies using nuclear reaction between 10B atoms and the neutron. Whether BNCT will succeed or not depends on tumor selective delivery of 10B compounds. e-Poly-L-lysine is a naturally occurring polyamine characterized by the peptide linkages between the carboxyl and e-amino groups of L-lysine. Because of high safety e-PLL is applied practically as a food additive due to its strong antimicrobial activity. In this study, we focus on a development of a novel polymeric delivery system for BNCT using biodegradable e-PLL conjugated with 10B-containing clusters (BSH). This polymeric boron carrier will be expected to deliver safely and efficiently into tumor tissues based on Enhanced Permeability and Retention (EPR) effect.
- Subjects :
- inorganic chemicals
chemistry.chemical_classification
Radiation
Radiochemistry
chemistry.chemical_element
Peptide
Boron clusters
Conjugated system
law.invention
Neutron capture
chemistry.chemical_compound
chemistry
law
Cell Line, Tumor
Polyamines
Humans
Polylysine
Tissue Distribution
Delivery system
Polyamine
Boron
Electron paramagnetic resonance
Subjects
Details
- ISSN :
- 18729800
- Volume :
- 69
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
- Accession number :
- edsair.doi.dedup.....0682c143707f9072183ddedeb0953e08