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Deciphering Metabolic Heterogeneity by Single-Cell Analysis

Authors :
Mazène Hochane
Stefan Semrau
Ron M. A. Heeren
Alireza Mashaghi
Peter Nemes
Sander J. Tans
Tom M J Evers
Imaging Mass Spectrometry (IMS)
RS: M4I - Imaging Mass Spectrometry (IMS)
Source :
Anal Chem, Analytical Chemistry, 91(21), 13314-13323. American Chemical Society
Publication Year :
2019

Abstract

Single-cell analysis provides insights into cellular heterogeneity and dynamics of individual cells. This feature highlights recent developments in key analytical techniques suited for single-cell metabolic analysis with a special focus on mass spectrometry-based analytical platforms and RNA-seq, as well as imaging techniques that reveal stochasticity in metabolism.

Details

Language :
English
ISSN :
00032700
Volume :
91
Issue :
21
Database :
OpenAIRE
Journal :
Analytical Chemistry
Accession number :
edsair.doi.dedup.....0664fd30d9c7cdd4e2a3967ea444d80e
Full Text :
https://doi.org/10.1021/acs.analchem.9b02410