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Deciphering Metabolic Heterogeneity by Single-Cell Analysis
- Source :
- Anal Chem, Analytical Chemistry, 91(21), 13314-13323. American Chemical Society
- Publication Year :
- 2019
-
Abstract
- Single-cell analysis provides insights into cellular heterogeneity and dynamics of individual cells. This feature highlights recent developments in key analytical techniques suited for single-cell metabolic analysis with a special focus on mass spectrometry-based analytical platforms and RNA-seq, as well as imaging techniques that reveal stochasticity in metabolism.
- Subjects :
- DYNAMICS
IONIZATION MASS-SPECTROMETRY
EMBRYONIC-CELLS
PROTEIN
Computational biology
010402 general chemistry
Proteomics
01 natural sciences
Mass Spectrometry
Article
Analytical Chemistry
Metabolomics
Single-cell analysis
CYTOMETRY
REVEALS
Animals
RNA-SEQ
Ionization mass spectrometry
Metabolic heterogeneity
Chemistry
010401 analytical chemistry
CAPILLARY-ELECTROPHORESIS
LIVE CELLS
0104 chemical sciences
Gene Expression Regulation
Cellular heterogeneity
PROTEOMICS
Single-Cell Analysis
Transcriptome
Nucleic Acid Amplification Techniques
Subjects
Details
- Language :
- English
- ISSN :
- 00032700
- Volume :
- 91
- Issue :
- 21
- Database :
- OpenAIRE
- Journal :
- Analytical Chemistry
- Accession number :
- edsair.doi.dedup.....0664fd30d9c7cdd4e2a3967ea444d80e
- Full Text :
- https://doi.org/10.1021/acs.analchem.9b02410