Genetics of Atopic Dermatitis

or Africans. 4 The prevalence of FLG mutations is similar in Europeans and Asians. In contrast, FLG mutations seem to be less common in African populations, although they have been less extensively studied, with the consequent possibility of underestimating the frequency of distinct FLG mutations. The strongest associations have been reported between FLG mutations and the risk of early-onset, persistent, and severe AD. 4