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Systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio levels are associated with keratoconus
- Source :
- Indian Journal of Ophthalmology, Vol 69, Iss 7, Pp 1725-1729 (2021), Indian Journal of Ophthalmology
- Publication Year :
- 2021
- Publisher :
- Wolters Kluwer Medknow Publications, 2021.
-
Abstract
- Purpose: The aim of this study was to assess the systemic immune-inflammation index (SII) levels, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in patients with keratoconus (KC). Methods: A total of 42 patients with KC (KC group) and 42 age- and sex-matched healthy subjects (control group) were included into this cross sectional study. Complete blood count parameters were assayed. SII, NLR, red cell distribution width (RDW), and PLR values were calculated. The SII value was calculated as follows: platelet count × (neutrophil/lymphocyte). Results: SII, NLR, RDW, and PLR values were significantly higher in KC group compared to control group [709 ± 236 vs. 418 ± 117 (P < 0.001), 2.5 ± 0.8 vs. 1.76 ± 0.3 (P < 0.001), 14.3 ± 1.6% vs. 12.9 ± 0.54% (P < 0.001), and 143 ± 36 vs. 106 ± 23 (P < 0.001), respectively]. Using the receiver operating characteristics (ROC) curve analysis to predict KC, the highest area under the curve (AUC) was determined SII (0.846 for SII, 0.778 for NLR, and 0.796 for PLR). Conclusion: SII, NLR, RDW, and PLR levels were significantly increased in patients with KC. This study supports the idea that several inflammatory pathways may play important role in the pathogenesis of this disorder. SII may be much better marker than NLR and PLR for predicting the inflammatory status of the disease.
- Subjects :
- medicine.medical_specialty
Keratoconus
Neutrophils
Lymphocyte
keratoconus
red cell distribution width
Gastroenterology
Pathogenesis
Internal medicine
systemic immune-inflammation index
medicine
Humans
Lymphocytes
Neutrophil to lymphocyte ratio
Retrospective Studies
Receiver operating characteristic
medicine.diagnostic_test
business.industry
Area under the curve
Complete blood count
Red blood cell distribution width
RE1-994
medicine.disease
Ophthalmology
medicine.anatomical_structure
Cross-Sectional Studies
inflammation
neutrophil/lymphocyte ratio
Original Article
platelet/lymphocyte ratio
business
Subjects
Details
- Language :
- English
- ISSN :
- 19983689 and 03014738
- Volume :
- 69
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Indian Journal of Ophthalmology
- Accession number :
- edsair.doi.dedup.....064b02b258d6ce9c9bc37b99eadd8f88