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Effect of Lamivudine Therapy on the Serum Covalently Closed-Circular (ccc) DNA of Chronic Hepatitis B Infection
- Source :
- The American Journal of Gastroenterology. 100:1099-1103
- Publication Year :
- 2005
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2005.
-
Abstract
- To determine the effect of 1-yr lamivudine treatment on serum covalently closed-circular DNA (cccDNA) level.Serum total HBV DNA and cccDNA levels at baseline, week 24, and week 52 were measured in 82 lamivudine-treated patients, 17 of whom received 1-yr placebo and acted as controls.There was a significant reduction in the cccDNA levels from baseline (median 3.0 x 10(6) copies/ml) to week 24 (33,476 copies/ml) and week 52 (48,694 copies/ml) (p0.001 for both). The median reduction in cccDNA level at week 24 and 52 were 2.21 and 2.12 logs, respectively, which were significantly greater than those of controls (0.31 log, p0.001; 0.2 log, p0.001, respectively). Fifteen patients (18.3%) developed YMDD mutations by week 52. Compared to patients without YMDD mutations, patients with YMDD mutations had significantly less median reduction of total HBV DNA level (4.44 vs 3.65 logs, respectively, p= 0.02) and cccDNA level (2.27 vs 1.65 logs, respectively, p= 0.016) at week 24 and significantly less median reduction of cccDNA at week 52 (2.35 vs 0.8 logs respectively, p0.001).One-year lamivudine treatment decreased serum cccDNA level by 2 logs. The chance of YMDD mutations at week 52 was related to the magnitude of viral suppression at week 24.
- Subjects :
- Adult
Male
Hepatitis B virus
Adolescent
Anti-HIV Agents
Amino Acid Motifs
medicine.disease_cause
Placebos
chemistry.chemical_compound
Hepatitis B, Chronic
Methionine
medicine
Humans
Isoleucine
Aspartic Acid
Hepatology
Reverse-transcriptase inhibitor
business.industry
RNA-Directed DNA Polymerase
Gastroenterology
Lamivudine
Valine
Middle Aged
Viral Load
Hepatitis B
Nucleotidyltransferase
medicine.disease
Virology
chemistry
DNA, Viral
Mutation
Reverse Transcriptase Inhibitors
Tyrosine
Female
DNA, Circular
business
Viral load
DNA
Follow-Up Studies
medicine.drug
Subjects
Details
- ISSN :
- 15720241 and 00029270
- Volume :
- 100
- Database :
- OpenAIRE
- Journal :
- The American Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....0644b865d5a43d26c07f4b33dd44f751