Back to Search
Start Over
Studies of bioactivity, conformation and pharmacokinetic profiles of site-specific PEGylated thymosin alpha 1 derivatives
- Source :
- Drug metabolism letters. 1(3)
- Publication Year :
- 2009
-
Abstract
- Site-specific mono-PEGylations were performed in different conformational regions of Thymosin alpha 1 (T alpha 1) by introducing one cysteine residue into the chosen site and coupling with thiol-specific mPEG-MAL reagent. Results demonstrated that PEGylated sites and regions influenced the conformations and pharmacokinetic profiles of the peptide greatly with following order: alpha-helix, beta-turn, random coil and terminals, but little on the immunoactivity.
- Subjects :
- Thymalfasin
Stereochemistry
Protein Conformation
Clinical Biochemistry
Pharmaceutical Science
Peptide
Polyethylene Glycols
Maleimides
Residue (chemistry)
Mice
Protein structure
Adjuvants, Immunologic
Animals
Pharmacology (medical)
Cell Proliferation
chemistry.chemical_classification
Mice, Inbred BALB C
Chemistry
Biochemistry (medical)
Thymosin
Random coil
Reagent
Spleen
Cysteine
Subjects
Details
- ISSN :
- 18740758
- Volume :
- 1
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Drug metabolism letters
- Accession number :
- edsair.doi.dedup.....063c4919c937f6478538b74ad3a9f428