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Alterations in anterior cingulate cortex myoinositol and aggression in veterans with suicidal behavior: A proton magnetic resonance spectroscopy study
- Source :
- Psychiatry Research: Neuroimaging. 276:24-32
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Studies investigating the neurochemical changes that correspond with suicidal behavior (SB) have not yielded conclusive results. Suicide correlates such as aggression have been used to explore risk factors for SB. Yet the neurobiological basis for the association between aggression and SB is unclear. Aggression and SB are both prevalent in veterans relative to civilian populations. The current study evaluated the relationship between brain chemistry in the anterior (ACC) and the posterior cingulate cortex (POC), as well as the relationship between aggression and SB in a veteran population using proton magnetic resonance spectroscopy (1H-MRS). Single-voxel MRS data at 3 Tesla (T) were acquired from the ACC and POC voxels using a 2-dimensional J-resolved point spectroscopy sequence and quantified using the ProFit algorithm. Participants also completed a structured diagnostic interview and a clinical battery. Our results showed that the myoinositol (mI)/H2O ratio in the ACC and POC was significantly higher in veterans who reported SB when compared to veterans who did not. The two groups did not differ significantly with regard to other metabolites. Second, verbal aggression and SB measures positively correlated with mI/H2O in the ACC. Finally, verbal aggression mediated the relationship between mI/H2O in the ACC and SB.
- Subjects :
- Adult
Male
Oncology
medicine.medical_specialty
Proton Magnetic Resonance Spectroscopy
Population
Neuroscience (miscellaneous)
Suicide, Attempted
Gyrus Cinguli
behavioral disciplines and activities
Suicidal Ideation
Young Adult
03 medical and health sciences
0302 clinical medicine
Neurochemical
Internal medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
education
Anterior cingulate cortex
Veterans
education.field_of_study
Verbal Behavior
business.industry
Aggression
Middle Aged
Proton magnetic resonance
030227 psychiatry
Psychiatry and Mental health
medicine.anatomical_structure
nervous system
Suicidal behavior
Case-Control Studies
Posterior cingulate
Endophenotype
Female
medicine.symptom
business
Inositol
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 09254927
- Volume :
- 276
- Database :
- OpenAIRE
- Journal :
- Psychiatry Research: Neuroimaging
- Accession number :
- edsair.doi.dedup.....0636f6dacd49bebc4fe10bf9d86884c8