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Quercetin: A promising phytochemical for the treatment of glioblastoma multiforme
- Source :
- BioFactors (Oxford, England)REFERENCES. 46(3)
- Publication Year :
- 2019
-
Abstract
- Quercetin, a plant-derived flavonoid, is known for its antitumor and antiproliferative activities. Glioblastoma multiforme (GBM), as a highly aggressive cerebrum tumor, has a poor prognosis that is approximately 12 months despite standard therapy. Therefore, because of the low effectiveness of the current therapeutic strategies, additional medications in combination with chemotherapy and radiotherapy are needed, which could improve the prognosis of GBM patients. Multiple lines of evidence have shown that quercetin regulates many proteins involved in the cellular signal transduction in GBM. In this review, recent findings on the targeting of particular signaling pathways by quercetin and the subsequent effect on the pathogenesis of GBM are presented and discussed.
- Subjects :
- 0301 basic medicine
medicine.medical_treatment
Clinical Biochemistry
Phytochemicals
Biochemistry
Antioxidants
Pathogenesis
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
medicine
Humans
heterocyclic compounds
Chemotherapy
business.industry
Brain Neoplasms
General Medicine
medicine.disease
Cellular signal transduction
nervous system diseases
Radiation therapy
030104 developmental biology
Phytochemical
chemistry
030220 oncology & carcinogenesis
Cancer research
Molecular Medicine
Quercetin
Signal transduction
business
Glioblastoma
Subjects
Details
- ISSN :
- 18728081
- Volume :
- 46
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- BioFactors (Oxford, England)REFERENCES
- Accession number :
- edsair.doi.dedup.....0635bf043594a59bbad68202306c9cb8