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A comparison of the potency of newly developed oximes (K027, K048) and commonly used oximes (obidoxime, HI-6) to counteract tabun-induced neurotoxicity in rats
- Source :
- Journal of applied toxicology : JAT. 26(4)
- Publication Year :
- 2006
-
Abstract
- The neuroprotective effects of newly developed oximes (K027, K048) and currently available oximes (obidoxime, HI-6) in combination with atropine in rats poisoned with tabun at a sublethal dose (170 microg kg(-1) i.m.; 80% of LD(50) value) were studied. The tabun-induced neurotoxicity was monitored using a functional observational battery and an automatic measurement of motor activity. The neurotoxicity of tabun was monitored at 24 h and 7 days following tabun challenge. The results indicate that the oxime HI-6 in combination with atropine was not able to protect the rats from the lethal effects of tabun. Two non-treated tabun-poisoned rats and one tabun-poisoned rat treated with atropine combined with HI-6 died within 2 h. On the other hand, all other tested oximes combined with atropine allowed all the tabun-poisoned rats to survive 7 days following tabun challenge. Both newly developed oximes combined with atropine seem to be sufficiently effective antidotes for a decrease in tabun-induced neurotoxicity in the case of sublethal poisoning although they are not able to eliminate tabun-induced neurotoxicity completely. The neuroprotective efficacy of obidoxime in combination with atropine approached the potency of newly developed oximes but the ability of the oxime HI-6 to counteract tabun-induced acute neurotoxicity was significantly lower, especially at 24 h after tabun poisoning. Due to their neuroprotective effects, both newly developed oximes appear to be suitable oximes for the antidotal treatment of acute tabun poisoning.
- Subjects :
- Obidoxime
Atropine
Male
Neurotoxicity Syndrome
Cholinesterase Reactivators
Obidoxime Chloride
medicine.medical_treatment
Pyridinium Compounds
Muscarinic Antagonists
Pharmacology
Motor Activity
Toxicology
chemistry.chemical_compound
Oximes
medicine
Animals
Rats, Wistar
Antidote
Tabun
Cholinesterase
biology
Behavior, Animal
Neurotoxicity
Oxime
medicine.disease
Organophosphates
Rats
Neuroprotective Agents
chemistry
Anesthesia
biology.protein
Neurotoxicity Syndromes
Cholinesterase Inhibitors
medicine.drug
Subjects
Details
- ISSN :
- 0260437X
- Volume :
- 26
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of applied toxicology : JAT
- Accession number :
- edsair.doi.dedup.....06225319d43b15cb4e3f34aece7578e4