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Natural Compounds against Neurodegenerative Diseases: Molecular Characterization of the Interaction of Catechins from Green Tea with Aβ1–42, PrP106–126, and Ataxin‐3 Oligomers
- Source :
- Chemistry – A European Journal. 20:13793-13800
- Publication Year :
- 2014
- Publisher :
- Wiley, 2014.
-
Abstract
- By combining NMR spectroscopy, transmission electron microscopy, and circular dichroism we have identified the structural determinants involved in the interaction of green tea catechins with Aβ1-42, PrP106-126, and ataxin-3 oligomers. The data allow the elucidation of their mechanism of action, showing that the flavan-3-ol unit of catechins is essential for interaction. At the same time, the gallate moiety, when present, seems to increase the affinity for the target proteins. These results provide important information for the rational design of new compounds with anti-amyloidogenic activity and/or molecular tools for the specific targeting of amyloid aggregates in vivo.
- Subjects :
- Circular dichroism
structure–activity relationship
Amyloid
Prions
Molecular Sequence Data
Nerve Tissue Proteins
Protein Aggregation, Pathological
Catechin
Catalysis
NMR spectroscopy
Molecular recognition
CHIM/06 - CHIMICA ORGANICA
medicine
Humans
Moiety
Structure–activity relationship
Amino Acid Sequence
Ataxin-3
Nuclear Magnetic Resonance, Biomolecular
Flavonoids
Biological Products
Amyloid beta-Peptides
Tea
Chemistry
Organic Chemistry
Rational design
Nuclear Proteins
Neurodegenerative Diseases
General Chemistry
Peptide Fragments
circular dichroism
Repressor Proteins
amyloid peptide
Biochemistry
Mechanism of action
Ataxin
molecular recognition
medicine.symptom
Subjects
Details
- ISSN :
- 15213765 and 09476539
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Chemistry – A European Journal
- Accession number :
- edsair.doi.dedup.....06166e8a9e68473997c8e98b141574b4