Back to Search
Start Over
Insomnia cycling with a 42-day infradian period: evidence for two uncoupled circadian oscillators?
- Source :
- Sleep medicine. 11(4)
- Publication Year :
- 2009
-
Abstract
- Objective To describe the unique case of a middle-aged woman with severe insomnia recurring with a regular infradian period without any other significant clinical condition. To infer the existence of a circadian dysfunction modeled according to the physical phenomenon of the “beats.” Patient/Methods A two-year prospective observation by means of a sleep log was performed during the patient’s normal life. She underwent one month of motor activity recording and also polysomnography, circadian rhythm of body core temperature and psychiatric evaluation during periods with and without insomnia. Results Visual inspection of the 293-day plot of the sleep log disclosed a regular 42-day rhythm of insomnia recurrence confirmed by a Discrete Fourier Transform. During the periods of insomnia, lasting 5–7 days, only moderate mood symptoms (depressive overlapping hypomaniac symptoms) were present. Treatment with sodium valproate was effective in curtailing insomnia. Conclusion The wax and wane infradian modulation of the sleep length suggested the presence of a basic mechanism similar to the physical phenomenon of the “beats,” i.e., a long period modulation of the amplitude of an oscillating system due to the interference of two uncoupled oscillators with a slightly different oscillation frequency. Hypothesizing a dysfunction of the circadian component of sleep, namely two uncoupled circadian cycles, a simple mathematical model estimated the difference of their periods of oscillation |34 ± 2 min| and reproduced the sleep-log data of the drug-free period of observation.
- Subjects :
- Adult
medicine.medical_specialty
Time Factors
Period (gene)
Polysomnography
Audiology
Motor Activity
Chronobiology Disorders
Severity of Illness Index
Body Temperature
Rhythm
Recurrence
Internal medicine
Sleep Initiation and Maintenance Disorders
medicine
Insomnia
Humans
Circadian rhythm
Prospective Studies
Muscle, Skeletal
Ultradian rhythm
medicine.diagnostic_test
Suprachiasmatic nucleus
Electromyography
General Medicine
Electrooculography
Endocrinology
Infradian rhythm
Female
medicine.symptom
Psychology
Subjects
Details
- ISSN :
- 18785506
- Volume :
- 11
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Sleep medicine
- Accession number :
- edsair.doi.dedup.....06089f0244d4da0056811e21761f72cc