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A highly sensitive fluorescent probe that quantifies transthyretin in human plasma as an early diagnostic tool of Alzheimer's disease
- Source :
- Chemical Communications. 55:10424-10427
- Publication Year :
- 2019
- Publisher :
- Royal Society of Chemistry (RSC), 2019.
-
Abstract
- The development of sensitive and reliable fluorescent probes for the early diagnosis of Alzheimer's disease (AD) is highly challenging and plays an important role in achieving effective treatments. Herein, we designed and synthesized an indole-based fluorophore for TTR in human plasma, an important hallmark of AD pathogenesis. This robust and simple fluorescent method allows quantification of TTR in the complex biological matrix.
- Subjects :
- endocrine system
Fluorophore
Computational biology
Disease
010402 general chemistry
01 natural sciences
Catalysis
chemistry.chemical_compound
Alzheimer Disease
Limit of Detection
Materials Chemistry
Humans
Prealbumin
Fluorescent Dyes
Amyloid beta-Peptides
biology
010405 organic chemistry
Metals and Alloys
nutritional and metabolic diseases
General Chemistry
Fluorescence
0104 chemical sciences
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Highly sensitive
Transthyretin
Spectrometry, Fluorescence
chemistry
Human plasma
Ceramics and Composites
biology.protein
Subjects
Details
- ISSN :
- 1364548X and 13597345
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Chemical Communications
- Accession number :
- edsair.doi.dedup.....0603d101844d15c2319bf1fef239f1d5