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Talking back: the podocytes and endothelial cells duke it out
- Source :
- Kidney International. 90:1157-1159
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Thrombotic microangiopathy has numerous causes and may result in chronic kidney disease with secondary glomerulosclerosis. Detailed analyses of this interplay of lesions have been lacking. Buob et al. report on their adult, mostly Caucasian patients, showing frequent sclerosis, most often of collapsing type, with worse prognosis than in those without segmental scars. The complex interplay of glomerular cells and possible ways in which the endothelial cells may talk back to the podocytes, and vice versa, are discussed.
- Subjects :
- Adult
0301 basic medicine
Pathology
medicine.medical_specialty
Thrombotic microangiopathy
Kidney Glomerulus
030232 urology & nephrology
Scars
Kidney
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Thrombotic Microangiopathies
Glomerulosclerosis, Focal Segmental
Podocytes
business.industry
Endothelial Cells
Glomerulosclerosis
medicine.disease
030104 developmental biology
medicine.anatomical_structure
Nephrology
medicine.symptom
business
Kidney disease
Subjects
Details
- ISSN :
- 00852538
- Volume :
- 90
- Database :
- OpenAIRE
- Journal :
- Kidney International
- Accession number :
- edsair.doi.dedup.....05f2e0212149cdeefa63bbe42e2ecc2d