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Top-down characterization data on the speciation of the Candida albicans immunome in candidemia
- Source :
- Data in Brief, Vol 6, Iss, Pp 257-261 (2016), Data in Brief, Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid, Consejería de Sanidad de la Comunidad de Madrid
- Publication Year :
- 2016
- Publisher :
- Elsevier, 2016.
-
Abstract
- The characterization of pathogen-specific antigenic proteins at the protein species level is crucial in the development and molecular optimization of novel immunodiagnostics, vaccines or immunotherapeutics for infectious diseases. The major requirements to achieve this molecular level are to obtain 100% sequence coverage and identify all post-translational modifications of each antigenic protein species. In this article, we show nearly complete sequence information for five discrete antigenic species of Candida albicans Tdh3 (glyceraldehyde-3-phosphate dehydrogenase), which have been reported to be differentially recognized both among candidemia patients and between candidemia and control patients. A comprehensive description of the top-down immunoproteomic strategy used for seroprofiling at the C. albicans protein species level in candidemia as well as for the chemical characterization of this immunogenic protein (based on high-resolution 2-DE, Western blotting, peptide mass fingerprinting, tandem mass spectrometry and de novo peptide sequencing) is also provided. The top-down characterization data on the speciation of the C. albicans immunome in candidemia presented here are related to our research article entitled “Seroprofiling at the Candida albicans protein species level unveils an accurate molecular discriminator for candidemia” (Pitarch et al., J. Proteomics, 2015, http://dx.doi.org/10.1016/j.jprot.2015.10.022). Keywords: Diagnosis, Candidemia, Invasive candidiasis, Protein species, Serologic response, Biomarkers, Immunoproteomics, Immunome, Serological proteome analysis, Glyceraldehyde-3-phosphate dehydrogenase
- Subjects :
- 0301 basic medicine
Serologic response
Proteomics
lcsh:Computer applications to medicine. Medical informatics
01 natural sciences
Immunoproteomics
Microbiology
03 medical and health sciences
Complete sequence
Protein species
Peptide mass fingerprinting
Diagnosis
Immunome
Candida albicans
lcsh:Science (General)
Data Article
Immunodiagnostics
Multidisciplinary
biology
Serological proteome analysis
010401 analytical chemistry
Candidemia
De novo peptide sequencing
biology.organism_classification
Corpus albicans
0104 chemical sciences
Invasive candidiasis
030104 developmental biology
lcsh:R858-859.7
Glyceraldehyde-3-phosphate dehydrogenase
Biomarkers
lcsh:Q1-390
Subjects
Details
- Language :
- English
- ISSN :
- 23523409
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Data in Brief
- Accession number :
- edsair.doi.dedup.....05e1f0b23d7581353bfe8d8bd1c01041