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Neurotrophin Trk receptors in the brain of a teleost fish, Nothobranchius furzeri
- Source :
- Microscopy Research and Technique. 75:81-88
- Publication Year :
- 2012
- Publisher :
- Wiley, 2012.
-
Abstract
- Trk neurotrophin receptors are transmembrane tyrosine kinase proteins known as TrkA, TrkB, and TrkC. TrkA is the high affinity receptor for nerve growth factor, TrkB is the one for both brain-derived neurotrophic factor and neurotrophin-4, and TrkC is the preferred receptor for neurotrophin-3. In the adult mammalian brain, neurotrophins are important regulators of neuronal function and plasticity. This study is based on Nothobranchius furzeri, a teleost fish that is becoming an ideal candidate as animal model for aging studies because its life expectancy in captivity is of just 3 months. In adult N. furzeri, all three investigated neurotrophin Trk receptors were immunohistochemically detected in each brain region. TrkA positive neuronal perikarya were localized in the dorsal and ventral areas of the telencephalon and in the cortical nucleus; TrkB immunoreactivity was observed in neuronal perikarya of the dorsal and ventral areas of the telencephalon, the diffuse inferior lobe of the hypothalamus, and Purkinje cells; TrkC positive neuronal perikarya were detected in the most aboral region of the telencephalon, in the magnocellular preoptic nucleus and in few neurons dispersed in the hypothalamus. Numerous positive fibers were widely distributed throughout the brain. Radial glial cells lining the mesencephalic and rhombencephalic ventricles showed immunoreactivity to all three Trks. These findings suggest an involvement of neurotrophins in many aspects of biology of adult N. furzeri. Microsc. Res. Tech Trk neurotrophin receptors are transmembrane tyrosine kinase proteins known as TrkA, TrkB, and TrkC. TrkA is the high affinity receptor for nerve growth factor, TrkB is the one for both brain-derived neurotrophic factor and neurotrophin-4, and TrkC is the preferred receptor for neurotrophin-3. In the adult mammalian brain, neurotrophins are important regulators of neuronal function and plasticity. This study is based on Nothobranchius furzeri, a teleost fish that is becoming an ideal candidate as animal model for aging studies because its life expectancy in captivity is of just 3 months. In adult N. furzeri, all three investigated neurotrophin Trk receptors were immunohistochemically detected in each brain region. TrkA positive neuronal perikarya were localized in the dorsal and ventral areas of the telencephalon and in the cortical nucleus; TrkB immunoreactivity was observed in neuronal perikarya of the dorsal and ventral areas of the telencephalon, the diffuse inferior lobe of the hypothalamus, and Purkinje cells; TrkC positive neuronal perikarya were detected in the most aboral region of the telencephalon, in the magnocellular preoptic nucleus and in few neurons dispersed in the hypothalamus. Numerous positive fibers were widely distributed throughout the brain. Radial glial cells lining the mesencephalic and rhombencephalic ventricles showed immunoreactivity to all three Trks. These findings suggest an involvement of neurotrophins in many aspects of biology of adult N. furzeri. © 2011 Wiley Periodicals, Inc.
- Subjects :
- Fish Proteins
animal structures
Histology
Neurotrophic factor
Tropomyosin receptor kinase B
Tropomyosin receptor kinase A
Settore BIO/09 - Fisiologia
Tropomyosin receptor kinase C
Nothobranchius furzeri
Cyprinodontiformes
Neurotrophic factors
Animals
Receptor, trkB
Low-affinity nerve growth factor receptor
Receptor, trkC
Receptor, trkA
Instrumentation
Neurons
biology
TrkA
TrkC
TrkB
Brain
biology.organism_classification
Medical Laboratory Technology
nervous system
Central nervous system
Trk receptor
embryonic structures
biology.protein
Anatomy
Neuroscience
Neurotrophin
Subjects
Details
- ISSN :
- 1059910X
- Volume :
- 75
- Database :
- OpenAIRE
- Journal :
- Microscopy Research and Technique
- Accession number :
- edsair.doi.dedup.....05dfe10fec44213ef652b4903bdcd487