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Prospective Evaluation of First-Line Erlotinib in Advanced Non-Small Cell Lung Cancer (NSCLC) Carrying an Activating EGFR Mutation: A Multicenter Academic Phase II Study in Caucasian Patients (FIELT)
- Source :
- PLoS ONE, Vol 11, Iss 3, p e0147599 (2016), PLoS ONE, PloS one, 11 (3, PLOS ONE
- Publication Year :
- 2016
- Publisher :
- Public Library of Science (PLoS), 2016.
-
Abstract
- INTRODUCTION: Epidermal Growth Factor Receptor (EGFR) tyrosine kinase inhibition is the preferred first-line treatment of advanced adenocarcinoma of the lung that harbors EGFR activating tyrosine kinase domain mutations. Most data available pertain to Asian populations in which such mutations are more prevalent. We report on the long-term results of first-line treatment with erlotinib in Caucasian patients with advanced adenocarcinoma of the lung that have a somatic EGFR mutation in their tumor.<br />SCOPUS: ar.j<br />info:eu-repo/semantics/published
- Subjects :
- 0301 basic medicine
Oncology
Male
DNA Mutational Analysis
Cancer Treatment
Gene Identification and Analysis
Psychologie appliquée
non-small cell lung cancer (NSCLC)
lcsh:Medicine
PACLITAXEL
Lung and Intrathoracic Tumors
Database and Informatics Methods
PLUS GEMCITABINE
0302 clinical medicine
Adenocarcinomas
Carcinoma, Non-Small-Cell Lung
Medicine and Health Sciences
Epidermal growth factor receptor
Prospective Studies
Erlotinib Hydrochloride
lcsh:Science
Aged, 80 and over
Multidisciplinary
biology
Adenocarcinoma of the Lung
Pharmaceutics
CHEMOTHERAPY
Middle Aged
Sciences bio-médicales et agricoles
OPEN-LABEL
FACTOR RECEPTOR MUTATIONS
ErbB Receptors
Treatment Outcome
030220 oncology & carcinogenesis
SURVIVAL
Adenocarcinoma
TRIAL
Female
Erlotinib
Tyrosine kinase
Biologie
Engineering sciences. Technology
medicine.drug
Research Article
Clinical Oncology
Adult
medicine.medical_specialty
European Continental Ancestry Group
Research and Analysis Methods
Carcinomas
White People
GEFITINIB
03 medical and health sciences
Gefitinib
Drug Therapy
Internal medicine
TYROSINE KINASE INHIBITORS
medicine
Adenocarcinoma of the lung
Genetics
Chemotherapy
Humans
Mutation Detection
Aged
business.industry
lcsh:R
Biology and Life Sciences
Cancers and Neoplasms
ADENOCARCINOMA
medicine.disease
Survival Analysis
Non-Small Cell Lung Cancer
respiratory tract diseases
030104 developmental biology
Biological Databases
Mutation
Mutation Databases
Cancer research
biology.protein
lcsh:Q
Receptor, Epidermal Growth Factor
Clinical Medicine
business
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 11
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....05d47512c871ae3faf670299777f2597