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Prospective Evaluation of First-Line Erlotinib in Advanced Non-Small Cell Lung Cancer (NSCLC) Carrying an Activating EGFR Mutation: A Multicenter Academic Phase II Study in Caucasian Patients (FIELT)

Authors :
Jean-Luc Canon
Guy Berchem
Christian Focan
Joanna Vermeij
D. Galdermans
Jacques De Greve
Benoit Colinet
Lionel Bosquée
Yves Humblet
Lore Decoster
Erik Teugels
Alex Dewaele
Denis Schallier
Anne-Pascale Meert
Jan P. van Meerbeeck
Peter Vuylsteke
Caroline Geers
Johan Vansteenkiste
Rosell, Rafael
Clinical sciences
Laboratory of Molecular and Medical Oncology
Department of Embryology and Genetics
Source :
PLoS ONE, Vol 11, Iss 3, p e0147599 (2016), PLoS ONE, PloS one, 11 (3, PLOS ONE
Publication Year :
2016
Publisher :
Public Library of Science (PLoS), 2016.

Abstract

INTRODUCTION: Epidermal Growth Factor Receptor (EGFR) tyrosine kinase inhibition is the preferred first-line treatment of advanced adenocarcinoma of the lung that harbors EGFR activating tyrosine kinase domain mutations. Most data available pertain to Asian populations in which such mutations are more prevalent. We report on the long-term results of first-line treatment with erlotinib in Caucasian patients with advanced adenocarcinoma of the lung that have a somatic EGFR mutation in their tumor.<br />SCOPUS: ar.j<br />info:eu-repo/semantics/published

Details

Language :
English
ISSN :
19326203
Volume :
11
Issue :
3
Database :
OpenAIRE
Journal :
PLoS ONE
Accession number :
edsair.doi.dedup.....05d47512c871ae3faf670299777f2597