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Age and organ damage correlate with poor survival in myeloma patients: meta-analysis of 1435 individual patient data from 4 randomized trials
- Source :
- Haematologica, 98(6), 980-987. Ferrata Storti Foundation, Bringhen, S, Mateos, M V, Zweegman, S, Larocca, A, Falcone, A P, Oriol, A, Rossi, D, Cavalli, M, Wijermans, P, Ria, R, Offidani, M, Lahuerta, J J, Liberati, A M, Mina, R, Callea, V, Schaafsma, M, Cerrato, C, Marasca, R, Franceschini, L, Evangelista, A, Teruel, A I, van der Holt, B, Montefusco, V, Ciccone, G, Boccadoro, M, San Miguel, J, Sonneveld, P & Palumbo, A 2013, ' Age and organ damage correlate with poor survival in myeloma patients: meta-analysis of 1435 individual patient data from 4 randomized trials ', Haematologica, vol. 98, no. 6, pp. 980-987 . https://doi.org/10.3324/haematol.2012.075051, Digital.CSIC. Repositorio Institucional del CSIC, instname
- Publication Year :
- 2013
-
Abstract
- This is an open-access paper.-- et al.<br />Thalidomide and bortezomib are extensively used to treat elderly myeloma patients. In these patients, treatmentrelated side effects are frequent and full drug doses difficult to tolerate. We retrospectively analyzed data from 1435 elderly patients enrolled in 4 European phase III trials including thalidomide and/or bortezomib. After a median follow up of 33 months (95%CI: 10-56 months), 513 of 1435 patients (36%) died; median overall survival was 50 months (95%CI: 46-60 months). The risk of death was increased in patients aged 75 years or over (HR 1.44, 95%CI: 1.20-1.72; P
- Subjects :
- Male
cancer incidence
peripheral neuropathy
Age Factors
Aged
Antineoplastic Combined Chemotherapy Protocols
Cause of Death
Female
Humans
Multiple Myeloma
Neoplasm Staging
Prognosis
Proportional Hazards Models
Randomized Controlled Trials as Topic
Treatment Outcome
retrospective study
thrombocytopenia
heart disease
cancer risk
law.invention
Randomized controlled trial
law
phase 3 clinical trial (topic)
cancer survival
Multiple myeloma
Cause of death
progression free survival
Bortezomib
disease course
article
Hematology
anemia
female
myeloma
gastrointestinal disease
medicine.drug
medicine.medical_specialty
overall survival
venous thromboembolism
male
Median follow-up
Internal medicine
medicine
follow up
neutropenia
human
second cancer
Adverse effect
business.industry
Proportional hazards model
medicine.disease
major clinical study
infection
Surgery
Thalidomide
Original Articles and Brief Reports
business
meta analysis
Subjects
Details
- ISSN :
- 03906078
- Database :
- OpenAIRE
- Journal :
- Haematologica, 98(6), 980-987. Ferrata Storti Foundation, Bringhen, S, Mateos, M V, Zweegman, S, Larocca, A, Falcone, A P, Oriol, A, Rossi, D, Cavalli, M, Wijermans, P, Ria, R, Offidani, M, Lahuerta, J J, Liberati, A M, Mina, R, Callea, V, Schaafsma, M, Cerrato, C, Marasca, R, Franceschini, L, Evangelista, A, Teruel, A I, van der Holt, B, Montefusco, V, Ciccone, G, Boccadoro, M, San Miguel, J, Sonneveld, P & Palumbo, A 2013, ' Age and organ damage correlate with poor survival in myeloma patients: meta-analysis of 1435 individual patient data from 4 randomized trials ', Haematologica, vol. 98, no. 6, pp. 980-987 . https://doi.org/10.3324/haematol.2012.075051, Digital.CSIC. Repositorio Institucional del CSIC, instname
- Accession number :
- edsair.doi.dedup.....05c8c87ad869a63b7f8a45f0bebc160f