Back to Search
Start Over
Subendocardial Viability Ratio Predicts Cardiovascular Mortality in Chronic Kidney Disease Patients
- Source :
- Blood Purification. 36:26-28
- Publication Year :
- 2013
- Publisher :
- S. Karger AG, 2013.
-
Abstract
- Background: The subendocardial viability ratio (SEVR), calculated by pulse wave analysis, is an index of myocardial oxygen supply and demand. Here we analyze the relation between SEVR and cardiovascular mortality in the chronic kidney disease (CKD) population of a post hoc analysis of a multicenter, prospective, randomized, nonblinded study. Methods: We studied 212 consecutive asymptomatic outpatients receiving care at 12 nephrology clinics in south Italy. Inclusion criteria were age >18 years, 6 months of follow-up before the enrollment and stage 3-4 CKD. Results: During follow-up, 34 subjects died, 29 of them for cardiovascular causes. SEVR correlated inversely with vascular calcifications (r = -0.37) and myocardial mass (r = -0.45); SEVR changed from 1.33 ± 0.24 to 1.36 ± 0.16 (p = NS; baseline and final values, respectively) in living patients, and from 1.16 ± 0.31 to 0.68 ± 0.26 in deceased patients (p < 0.001). Kaplan-Meier curves show that that a greater reduction of SEVR values during the study (third tertile) significantly predicts cardiovascular mortality (p < 0.0001). Conclusions: This post hoc analysis shows that a reduction of SEVR values impacts cardiovascular mortality in CKD patients.
- Subjects :
- Male
Nephrology
medicine.medical_specialty
Population
Pulse Wave Analysis
Asymptomatic
Internal medicine
Post-hoc analysis
medicine
Humans
Prospective Studies
Renal Insufficiency, Chronic
Stage (cooking)
Prospective cohort study
education
Aged
Cardiovascular mortality
education.field_of_study
business.industry
Hematology
General Medicine
Middle Aged
Prognosis
medicine.disease
Cardiovascular Diseases
Cardiology
Female
medicine.symptom
business
Follow-Up Studies
Kidney disease
Subjects
Details
- ISSN :
- 14219735 and 02535068
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Blood Purification
- Accession number :
- edsair.doi.dedup.....05b32134d954adb5ea6c49d9b159807c