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Detection and imaging of gadolinium accumulation in human bone tissue by micro- and submicro-XRF
- Source :
- Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020), Scientific Reports, 'Scientific Reports ', vol: 10, pages: 6301-1-6301-9 (2020), Scientific reports, 10 (1), Art.Nr.: 6301
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group, 2020.
-
Abstract
- Gadolinium-based contrast agents (GBCAs) are frequently used in patients undergoing magnetic resonance imaging. In GBCAs gadolinium (Gd) is present in a bound chelated form. Gadolinium is a rare-earth element, which is normally not present in human body. Though the blood elimination half-life of contrast agents is about 90 minutes, recent studies demonstrated that some tissues retain gadolinium, which might further pose a health threat due to toxic effects of free gadolinium. It is known that the bone tissue can serve as a gadolinium depot, but so far only bulk measurements were performed. Here we present a summary of experiments in which for the first time we mapped gadolinium in bone biopsy from a male patient with idiopathic osteoporosis (without indication of renal impairment), who received MRI 8 months prior to biopsy. In our studies performed by means of synchrotron radiation induced micro- and submicro-X-ray fluorescence spectroscopy (SR-XRF), gadolinium was detected in human cortical bone tissue. The distribution of gadolinium displays a specific accumulation pattern. Correlation of elemental maps obtained at ANKA synchrotron with qBEI images (quantitative backscattered electron imaging) allowed assignment of Gd structures to the histological bone structures. Follow-up beamtimes at ESRF and Diamond Light Source using submicro-SR-XRF allowed resolving thin Gd structures in cortical bone, as well as correlating them with calcium and zinc.
- Subjects :
- Male
0301 basic medicine
Technology
Time Factors
Biopsy
Gadolinium
Contrast Media
chemistry.chemical_element
Human bone
lcsh:Medicine
Imaging techniques
Bone tissue
Article
Imaging
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Light source
Nuclear magnetic resonance
Cortical Bone
medicine
Humans
Tissue Distribution
Chelation
Bone
lcsh:Science
Multidisciplinary
medicine.diagnostic_test
Chemistry
lcsh:R
Spectrometry, X-Ray Emission
Magnetic resonance imaging
Middle Aged
Magnetic Resonance Imaging
030104 developmental biology
medicine.anatomical_structure
Osteoporosis
Cortical bone
lcsh:Q
ddc:600
Synchrotrons
Half-Life
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....05af5fd732c65d300206cd295d4fb56d