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Feasibility and Immune Response of WT1 Peptide Vaccination in Combination with OK-432 for Paediatric Solid Tumors
- Source :
- Anticancer Research. 38
- Publication Year :
- 2018
- Publisher :
- Anticancer Research USA Inc., 2018.
-
Abstract
- Background/aim Wilms' tumor 1 (WT1) peptide-based vaccination has been reported for its potential usefulness in targeting several cancers. The adjuvant drug OK-432 is known to have potent immunomodulation and therapeutic properties when applied in cancer treatment and may, thus, be important to trigger the appropriate immunological response in paediatric patients with a solid tumor that are vaccinated with a WT1 peptide. Patients and methods Paediatric patients with a solid tumor were vaccinated with a WT1 peptide and OK-432 once every 2 weeks, for a total of seven times. Results Of the 24 patients, 18 completed the scheduled vaccinations. Sixteen patients had local skin symptoms and/or fever. In 1 patient, anaphylactic symptoms emerged at the time of the final injection, but these quickly subsided after the treatment. WT1-specific immunological responses were observed in 4 patients (22.2%). WT1 and HLA class I expression were confirmed in 100% and 85% of primary tumors, respectively. Conclusion WT1 peptide vaccine therapy combined with OK-432 appears to be relatively safe for children. However further studies in a larger number of patients are necessary to confirm its safety and efficacy.
- Subjects :
- Adult
Male
0301 basic medicine
Drug
Oncology
Cancer Research
medicine.medical_specialty
Adolescent
media_common.quotation_subject
T cell
medicine.medical_treatment
Human leukocyte antigen
Cancer Vaccines
Picibanil
Young Adult
03 medical and health sciences
0302 clinical medicine
Immune system
Adjuvants, Immunologic
Neoplasms
Internal medicine
medicine
Humans
Child
WT1 Proteins
media_common
business.industry
Vaccination
General Medicine
Immunotherapy
Pediatric cancer
Immunity, Innate
Treatment Outcome
030104 developmental biology
medicine.anatomical_structure
Child, Preschool
030220 oncology & carcinogenesis
Feasibility Studies
Female
business
Adjuvant
Subjects
Details
- ISSN :
- 17917530 and 02507005
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Anticancer Research
- Accession number :
- edsair.doi.dedup.....05adc5695f2df33d61e21c21e27ca042