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Applying Label-Free Quantitation to Top Down Proteomics
- Source :
- Analytical Chemistry
- Publication Year :
- 2014
- Publisher :
- American Chemical Society (ACS), 2014.
-
Abstract
- With the prospect of resolving whole protein molecules into their myriad proteoforms on a proteomic scale, the question of their quantitative analysis in discovery mode comes to the fore. Here, we demonstrate a robust pipeline for the identification and stringent scoring of abundance changes of whole protein forms
- Subjects :
- Proteomics
0303 health sciences
Chemistry
Pipeline (computing)
010401 analytical chemistry
Proteins
Saccharomyces cerevisiae
Computational biology
Replicate
Top-down proteomics
01 natural sciences
Molecular biology
Article
Histone Deacetylases
0104 chemical sciences
Analytical Chemistry
03 medical and health sciences
Label-free quantification
Volcano plot
Biological variation
Mutation
030304 developmental biology
Total protein
Subjects
Details
- ISSN :
- 15206882 and 00032700
- Volume :
- 86
- Database :
- OpenAIRE
- Journal :
- Analytical Chemistry
- Accession number :
- edsair.doi.dedup.....05a65da4e5cfe8b067a905c73bccb8ea