Back to Search Start Over

Intraoperative Anaphylactic Reaction: Is it the Floseal?

Intraoperative Anaphylactic Reaction: Is it the Floseal?

Authors :
Jan Klamar
David R. Stukus
Brianne M. Bordes
Allan Beebe
Brian Schloss
David P. Martin
Walter P. Samora
Joseph D. Tobias
Source :
The Journal of Pediatric Pharmacology and Therapeutics. 21:358-365
Publication Year :
2016
Publisher :
Pediatric Pharmacy Advocacy Group, 2016.

Abstract

When hemodynamic or respiratory instability occurs intraoperatively, the inciting event must be determined so that a therapeutic plan can be provided to ensure patient safety. Although generally uncommon, one cause of cardiorespiratory instability is anaphylactic reactions. During anesthetic care, these most commonly involve neuromuscular blocking agents, antibiotics, or latex. Floseal is a topical hemostatic agent that is frequently used during orthopedic surgical procedures to augment local coagulation function and limit intraoperative blood loss. As these products are derived from human thrombin, animal collagen, and animal gelatin, allergic phenomenon may occur following their administration. We present 2 pediatric patients undergoing posterior spinal fusion who developed intraoperative hemodynamic and respiratory instability following use of the topical hemostatic agent, Floseal. Previous reports of such reactions are reviewed, and the perioperative care of patients with intraoperative anaphylaxis is discussed.

Details

ISSN :
15516776
Volume :
21
Database :
OpenAIRE
Journal :
The Journal of Pediatric Pharmacology and Therapeutics
Accession number :
edsair.doi.dedup.....05a5dd35be055a36445e3a171fd7d9da
Full Text :
https://doi.org/10.5863/1551-6776-21.4.358