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The gut microbiota and host health: a new clinical frontier
- Source :
- Gut, Gut 65 (2016) 2, Gut, 65(2), 330-339
- Publication Year :
- 2015
- Publisher :
- BMJ Publishing Group, 2015.
-
Abstract
- Over the last 10–15 years, our understanding of the composition and functions of the human gut microbiota has increased exponentially. To a large extent, this has been due to new ‘omic’ technologies that have facilitated large-scale analysis of the genetic and metabolic profile of this microbial community, revealing it to be comparable in influence to a new organ in the body and offering the possibility of a new route for therapeutic intervention. Moreover, it might be more accurate to think of it like an immune system: a collection of cells that work in unison with the host and that can promote health but sometimes initiate disease. This review gives an update on the current knowledge in the area of gut disorders, in particular metabolic syndrome and obesity-related disease, liver disease, IBD and colorectal cancer. The potential of manipulating the gut microbiota in these disorders is assessed, with an examination of the latest and most relevant evidence relating to antibiotics, probiotics, prebiotics, polyphenols and faecal microbiota transplantation.
- Subjects :
- MUCOSA-ASSOCIATED MICROBIOTA
0301 basic medicine
Health Status
Disease
Gut flora
Pouchitis
Inflammatory bowel disease
COLORECTAL-CANCER
Crohn Disease
Microbiologie
Non-alcoholic Fatty Liver Disease
1114 Paediatrics And Reproductive Medicine
biology
INTESTINAL BACTERIA
Liver Diseases
Gastrointestinal Microbiome
Gastroenterology
RANDOMIZED CONTROLLED-TRIAL
PRIMARY SCLEROSING CHOLANGITIS
Ulcerative colitis
Microbiota intestinale umano
CROHNS-DISEASE
ULCERATIVE-COLITIS
Life Sciences & Biomedicine
HUMAN COLONIC MICROBIOTA
Microbiology
digestive system
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
Autoimmune Diseases
03 medical and health sciences
Immune system
medicine
Life Science
Animals
Humans
Obesity
Liver Diseases, Alcoholic
FATTY LIVER-DISEASE
VLAG
Science & Technology
Gastroenterology & Hepatology
Bacteria
business.industry
Probiotics
Recent Advances in Basic Science
Polyphenols
1103 Clinical Sciences
medicine.disease
biology.organism_classification
Inflammatory Bowel Diseases
030104 developmental biology
Prebiotics
Immunology
FECAL MICROBIOTA
Colitis, Ulcerative
Metabolic syndrome
business
INFLAMMATORY-BOWEL-DISEASE
Subjects
Details
- Language :
- English
- ISSN :
- 14683288 and 00175749
- Volume :
- 65
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Gut
- Accession number :
- edsair.doi.dedup.....05a44bd3698d1a1fcb1142e0909218e3