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The role of phosphate in the secretion of parathyroid hormone in man
- Source :
- Journal of Clinical Investigation. 49:2146-2149
- Publication Year :
- 1970
- Publisher :
- American Society for Clinical Investigation, 1970.
-
Abstract
- In man, oral administration of 1 g of phosphorus resulted in a 60-125% increase in serum immunoassayable parathyroid hormone (PTH) concentration. Peak PTH levels were attained in 1 hr, and PTH returned to base line levels in 2 hr. This increase in PTH appeared to be initiated by a very small decrease of total and ionized calcium and was abolished by a calcium infusion. There was no correlation between serum phosphorus and PTH. The experiments show that oral phosphorus administration initiates a calcium-mediated control system for PTH secretion and that this system operates very sensitively in man.
- Subjects :
- Adult
Male
endocrine system
medicine.medical_specialty
Time Factors
Radioimmunoassay
Parathyroid hormone
chemistry.chemical_element
Calcium
Phosphates
chemistry.chemical_compound
Oral administration
Internal medicine
medicine
Humans
Secretion
Calcium metabolism
Phosphorus
Articles
General Medicine
Phosphate
Endocrinology
chemistry
Parathyroid Hormone
Female
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 00219738
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Investigation
- Accession number :
- edsair.doi.dedup.....059013ea7a233d0ad1ba2b5072a642fa