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Long-Term Outcomes of Infants with Congenital Zika Virus Infection in Ecuador: A Retrospective Longitudinal Study
- Source :
- Journal of Tropical Pediatrics. 67
- Publication Year :
- 2020
- Publisher :
- Oxford University Press (OUP), 2020.
-
Abstract
- Background Few congenital Zika syndrome (CZS) cases have been notified in Ecuador and, to our knowledge, there are no significant published studies dealing with their clinical evolution. We present a detailed clinical characterization of 21 children with congenital Zika virus (ZIKV) infection born in Ecuador who were followed up until September 2019. Methods We did a retrospective longitudinal study of children attended by the infectious disease specialists of Francisco Icaza Bustamante Children’s Hospital (Guayaquil) due to congenital ZIKV infection suspicion. The inclusion criteria consisted of laboratory confirmed diagnosis of congenital ZIKV infection. Results Sixteen of these 21 cases of congenital ZIKV infection showed clinical, neuroimaging and laboratory findings strongly suggestive of CZS and 5 children showed laboratory findings compatible with congenital ZIKV infection without congenital manifestations associated to CZS. All children with CZS showed neurodevelopmental delay, spasticity and hyperreflexia during follow-up, whereas the majority of them (14/15) experienced recurrent epileptic seizures and dysphagia (12/13). Two CZS cases died during follow-up. Visual evoked potential and hearing screening with acoustically evoked auditory brainstem response were abnormal in 50% and 37.5% of CZS cases, respectively. Congenital ZIKV infection without findings consistent with CZS at birth was not clinically relevant at 23 months of age in the five cases of our cohort. Conclusions Severe neurodevelopmental delay, severe microcephaly, epileptic seizures and dysphagia were present at 2 years of age in most CZS cases of our cohort.
- Subjects :
- Pediatrics
medicine.medical_specialty
Longitudinal study
Microcephaly
030231 tropical medicine
Hyperreflexia
Zika virus
03 medical and health sciences
Epilepsy
0302 clinical medicine
Pregnancy
medicine
Humans
Longitudinal Studies
030212 general & internal medicine
Pregnancy Complications, Infectious
Child
Retrospective Studies
biology
Zika Virus Infection
business.industry
Infant
Zika Virus
medicine.disease
biology.organism_classification
Dysphagia
Infectious Diseases
Auditory brainstem response
Pediatrics, Perinatology and Child Health
Cohort
Evoked Potentials, Visual
Female
Ecuador
medicine.symptom
business
Subjects
Details
- ISSN :
- 14653664 and 01426338
- Volume :
- 67
- Database :
- OpenAIRE
- Journal :
- Journal of Tropical Pediatrics
- Accession number :
- edsair.doi.dedup.....058fde11bd200d242b888d3b5901994b