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Serum Levels and Clinical Effect of Flucloxacillin in Patients with Staphylococcal Infections
- Source :
- Scandinavian Journal of Infectious Diseases. 6:273-278
- Publication Year :
- 1974
- Publisher :
- Informa UK Limited, 1974.
-
Abstract
- 25 patients with infections with penicillinase-producing methicillin-sensitive Staphylococcus aureus strains were treated by oral administration of flucloxacillin. In 12 of the patients the serum concentration was measured after administration of 0.5 or 1.0 g 3 times a day. After the smaller dose the average serum level was 24 μg/ml in fasting patients and 17 μg/ml in those who had taken the drug in association with a meal. The corresponding values after administration of 1.0 g were 35 and 26 μg/ml, respectively. In both groups the peak serum level occurred, on the average, one hour after intake of the antibiotic. In 14 of 16 patients with deep infections the effect of treatment was regarded as good. In 9 patients with skin infections the effect was initially good. Three of the patients complained of malaise, but the symptom could not be ascribed to the antibiotic.
- Subjects :
- Adult
Male
Microbiology (medical)
medicine.medical_specialty
Adolescent
medicine.drug_class
Staphylococcus
Antibiotics
Administration, Oral
Pharmacology
Skin infection
medicine.disease_cause
Staphylococcal infections
Gastroenterology
Blood serum
Cloxacillin
Oral administration
Internal medicine
medicine
Humans
Surgical Wound Infection
Child
Aged
Clinical Trials as Topic
General Immunology and Microbiology
business.industry
Furunculosis
General Medicine
Middle Aged
Staphylococcal Infections
medicine.disease
Infectious Diseases
Staphylococcus aureus
Child, Preschool
Female
Flucloxacillin
business
medicine.drug
Subjects
Details
- ISSN :
- 16511980 and 00365548
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Scandinavian Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....05784d474ce837a1ad19ca396af1af6c