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Designing and building oncolytic viruses
- Source :
- Future Virology
- Publication Year :
- 2017
- Publisher :
- Future Medicine Ltd, 2017.
-
Abstract
- Oncolytic viruses (OVs) are engineered and/or evolved to propagate selectively in cancerous tissues. They have a dual mechanism of action; direct killing of infected cancer cells cross-primes anticancer immunity to boost the killing of uninfected cancer cells. The goal of the field is to develop OVs that are easily manufactured, efficiently delivered to disseminated sites of cancer growth, undergo rapid intratumoral spread, selectively kill tumor cells, cause no collateral damage and pose no risk of transmission in the population. Here we discuss the many virus engineering strategies that are being pursued to optimize delivery, intratumoral spread and safety of OVs derived from different virus families. With continued progress, OVs have the potential to transform the paradigm of cancer care.
- Subjects :
- 0301 basic medicine
Anticancer immunity
education.field_of_study
Population
virus targeting
Cancer
Review
Biology
virus engineering
medicine.disease
Virology
Virus
Oncolytic virus
03 medical and health sciences
030104 developmental biology
Cancer cell
medicine
cancer therapy
oncolytic immunotherapy
Virotherapy
education
oncolytic virotherapy
Virus classification
Subjects
Details
- ISSN :
- 17460808 and 17460794
- Volume :
- 12
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Future Virology
- Accession number :
- edsair.doi.dedup.....0558844a33c7819953897923d27150c2
- Full Text :
- https://doi.org/10.2217/fvl-2016-0129