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The prognostic significance of DNA cytophotometry and proliferation index (Ki-67) in giant cell tumors of bone
- Publication Year :
- 1999
- Publisher :
- Springer-Verlag, 1999.
-
Abstract
- We studied DNA ploidy by smear cytophotometry and proliferation activity by Ki-67 MIB immunohistochemistry in 69 primary and recurrent giant cell tumors (GCT) from 50 randomly selected patients. The obtained results were evaluated with comparisons made to the available clinical data. From the 46 primary tumors 63% showed diploidy and 37% aneuploidy. A significantly (P=0.026) higher recurrence rate (64%) was observed in aneuploid than in diploid tumors (31%). In the course of the recurrences, both the ratio of aneuploid tumors as well as the proliferation index of the tumors increased, though the degree of the latter was non-significant. Aneuploidy did not mean an unambiguous tendency towards malignant transformation; however, a close follow-up of recurrent aneuploid tumors, and wide excision of the recurrence instead of intralesional curettage are the recommended procedures. The DNA cytophotometry and proliferation index of GCTs – as compared to other histologic examinations – are of prognostic value in the evaluation of the recurrence potential of the GCTs.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Proliferation index
Adolescent
Aneuploidy
Bone Neoplasms
Malignant transformation
Predictive Value of Tests
Medicine
Humans
Orthopedics and Sports Medicine
Giant Cell Tumors
Aged
Retrospective Studies
Giant Cell Tumor of Bone
Original Paper
Chi-Square Distribution
biology
business.industry
DNA, Neoplasm
Middle Aged
medicine.disease
Diploidy
Cytophotometry
Ki-67 Antigen
Ki-67
biology.protein
Immunohistochemistry
Surgery
Female
Neoplasm Recurrence, Local
business
Giant-cell tumor of bone
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....0556be6d0db00557061e010f1bab524d