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Efficacy of Antiretroviral Agents against Murine Replication-Competent Retrovirus Infection in Human Cells
- Source :
- Journal of Virology. 73:8813-8816
- Publication Year :
- 1999
- Publisher :
- American Society for Microbiology, 1999.
-
Abstract
- Retroviral vectors for gene therapy are designed to minimize the occurrence of replication-competent retrovirus (RCR); nonetheless, it is possible that a vector-derived RCR could establish an infection in a patient. Since the efficacy of antiretroviral agents can be impacted by interactions between virus, host cell, and drug, five commonly used antiretroviral drugs were evaluated for their abilities to inhibit the replication of a murine leukemia virus (MLV)-derived RCR in human cells. The results obtained indicate that the combination of nucleoside analogs zidovudine and dideoxyinosine with the protease inhibitor indinavir effectively inhibits MLV-derived RCR replication in three human cell lines. In addition, MLV-derived RCR was found to be inherently resistant to the nucleoside analogs lamivudine and stavudine, suggesting that mutations conferring resistance to nucleoside analogs in human immunodeficiency virus type 1 have the same effect even in an alternative viral backbone.
- Subjects :
- viruses
Genetic Vectors
Immunology
Indinavir
Virus Replication
Microbiology
Cell Line
Zidovudine
Retrovirus
Virology
medicine
Humans
Protease inhibitor (pharmacology)
biology
Nucleoside analogue
Stavudine
Gene Transfer Techniques
Gene Therapy
Genetic Therapy
biology.organism_classification
Leukemia Virus, Murine
Didanosine
Viral replication
Insect Science
Reverse Transcriptase Inhibitors
Replication Competent Retrovirus
medicine.drug
Subjects
Details
- ISSN :
- 10985514 and 0022538X
- Volume :
- 73
- Database :
- OpenAIRE
- Journal :
- Journal of Virology
- Accession number :
- edsair.doi.dedup.....055459ff9730760349c597dc5aaaf146