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Identification of inhibitors for UDP-galactopyranose mutase
- Source :
- Journal of the American Chemical Society. 126(34)
- Publication Year :
- 2004
-
Abstract
- The flavoenzyme uridine 5'-diphosphate (UDP)-galactopyranose mutase (UGM) plays a key role in the cell wall biosynthesis of many pathogens, including Mycobacterium tuberculosis. Using a synthetic fluorescent ligand, we screened 16 000 compounds in a fluorescence polarization assay. Effective inhibitors of UGM were identified.
- Subjects :
- Fluorescence Polarization
Biochemistry
Catalysis
Substrate Specificity
Mycobacterium tuberculosis
chemistry.chemical_compound
Inhibitory Concentration 50
Colloid and Surface Chemistry
Mutase
Enzyme Inhibitors
Intramolecular Transferases
Chromatography, High Pressure Liquid
biology
Chemistry
General Chemistry
biology.organism_classification
Ligand (biochemistry)
Enterobacteriaceae
Uridine
Kinetics
Enzyme inhibitor
biology.protein
Fluorescence anisotropy
Bacteria
Subjects
Details
- ISSN :
- 00027863
- Volume :
- 126
- Issue :
- 34
- Database :
- OpenAIRE
- Journal :
- Journal of the American Chemical Society
- Accession number :
- edsair.doi.dedup.....054e4cd573aa73371425dd14fbcc834b