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A Left-Handed Solution to Peptide Inhibition of the p53-MDM2 Interaction
- Source :
- Angewandte Chemie. 122:3731-3734
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- Throwing tumors a left hook punch: The oncoprotein MDM2 negatively regulates the activity and stability of the tumor suppressor protein p53, and is an important molecular target for anticancer therapy. Mirror image phage display identifies a high-affinity D-peptide ligand of MDM2 that can be developed into a potent and protease-resistant p53 activator with potential antitumor activity.
- Subjects :
- Phage display
Molecular Sequence Data
Peptide
Ligands
Article
Catalysis
law.invention
Protein structure
Proto-Oncogene Proteins c-mdm2
law
Humans
Amino Acid Sequence
Enzyme Inhibitors
Peptide sequence
chemistry.chemical_classification
biology
Activator (genetics)
Stereoisomerism
General Chemistry
General Medicine
Molecular biology
Cell biology
chemistry
Drug Design
biology.protein
Mdm2
Suppressor
Peptides
Subjects
Details
- ISSN :
- 00448249
- Volume :
- 122
- Database :
- OpenAIRE
- Journal :
- Angewandte Chemie
- Accession number :
- edsair.doi.dedup.....054717bc3258e0e4b70f685ece2e566b