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Multiscale analyses of the bone-implant interface
- Source :
- Journal of dental research. 94(3)
- Publication Year :
- 2015
-
Abstract
- Implants placed with high insertion torque (IT) typically exhibit primary stability, which enables early loading. Whether high IT has a negative impact on peri-implant bone health, however, remains to be determined. The purpose of this study was to ascertain how peri-implant bone responds to strains and stresses created when implants are placed with low and high IT. Titanium micro-implants were inserted into murine femurs with low and high IT using torque values that were scaled to approximate those used to place clinically sized implants. Torque created in peri-implant tissues a distribution and magnitude of strains, which were calculated through finite element modeling. Stiffness tests quantified primary and secondary implant stability. At multiple time points, molecular, cellular, and histomorphometric analyses were performed to quantitatively determine the effect of high and low strains on apoptosis, mineralization, resorption, and collagen matrix deposition in peri-implant bone. Preparation of an osteotomy results in a narrow zone of dead and dying osteocytes in peri-implant bone that is not significantly enlarged in response to implants placed with low IT. Placing implants with high IT more than doubles this zone of dead and dying osteocytes. As a result, peri-implant bone develops micro-fractures, bone resorption is increased, and bone formation is decreased. Using high IT to place an implant creates high interfacial stress and strain that are associated with damage to peri-implant bone and therefore should be avoided to best preserve the viability of this tissue.
- Subjects :
- Male
Materials science
Bone-Implant Interface
Cell Survival
Surface Properties
medicine.medical_treatment
Finite Element Analysis
Dentistry
Strain (injury)
Apoptosis
Matrix (biology)
Osteotomy
Osteocytes
Osseointegration
Bone resorption
Dental Prosthesis Retention
Dental Materials
Mice
Calcification, Physiologic
Osteogenesis
Elastic Modulus
medicine
Animals
Femur
Bone Resorption
Pliability
General Dentistry
Dental Implants
Titanium
Cell Death
business.industry
Dental Implantation, Endosseous
Research Reports
medicine.disease
Resorption
Biomechanical Phenomena
Torque
Implant
Bone Remodeling
Collagen
Stress, Mechanical
business
Biomedical engineering
Subjects
Details
- ISSN :
- 15440591
- Volume :
- 94
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of dental research
- Accession number :
- edsair.doi.dedup.....054609be20deaa922266cfd23b3a80d8